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Products:Cell Biology >> Apoptosis >> Receptors >> Death Receptors
Overview
Product name
Anti-CD95 antibody
See all CD95 products (37) ...
Description
Chicken polyclonal to CD95
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Fusion protein: KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFC HKPCPPGERK ARDCTVNGD EPDCVPCQE GKEYTDKAHF SSKCRRCRLC DEGHGLEVEI NCTRTQNTKCR CKPNFFCNSTV CEHCDPCTKCE HGIIKECTLTS NTKC, corresponding to amino acids 21-165 of Human Fas.
KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQ FC HKPCPPGERK ARDCTVNGD EPDCVPCQE GKEYTD KAHF SSKCRRCRLC DEGHGLEVEI NCTRTQNTKC R C KPNFFCNSTV CEHCDPCTKC E HGIIKECTLT S NTKC
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Peptide immunogen affinity column
Clonality
Polyclonal
Isotype
IgY
Research areas
Cancer >> Signal transduction >> Other
Cancer >> Growth factors >> TNF
Signal Transduction >> Growth Factors/Hormones >> TNF
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Innate Immunity >> Cytokines >> TNF Superfamily
Immunology >> Cell Type Markers >> CD >> Cytokines
Immunology >> Immune Interventions >> Transplantation
Cell Biology >> Apoptosis >> Intracellular >> Associated Proteins
Cell Biology >> Apoptosis >> Receptors >> Death Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab14022 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500Detects a band of approximately 62 kDa.
Target
Function
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Tissue specificity
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
Involvement in disease
Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.
Domain
Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP25445
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ALPS 1A antibody
- ALPS1A antibody
- APO 1 antibody
see all
Database links
- Entrez Gene: 355 Human
- Omim: 134637 Human
- SwissProt: P25445 Human
- Unigene: 244139 Human
References for Anti-CD95 antibody (ab14022)
ab14022 has not yet been referenced specifically in any publications.
Publishing research using ab14022? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"