Anti-CD96 antibody (ab128828)
- Product nameAnti-CD96 antibodySee all CD96 primary antibodies ...
- DescriptionRabbit polyclonal to CD96
- Tested applicationsWB more details
- Species reactivityReacts with: Human
Synthetic peptide corresponding to a region within C-terminal amino acids 429-478 (TTPQPSNSSM TTRGFNYPWT SSGTDTKKSV SRIPSETYSS SPSGAGSTLH) of Human CD96 (NP_937839).
- Positive controlHeLa cell lysate
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferConstituents: 97% PBS, 2% Sucrose
- Concentration information loading...
- PurityImmunogen affinity purified
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab128828 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 66 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
- FunctionMay be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
- Tissue specificityExpressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
- Involvement in diseaseDefects in CD96 are a cause of C syndrome (CSYN) [MIM:211750]; also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. Note=A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
Defects in CD96 are a cause of C-like syndrome (CLSYN) [MIM:605039]; also called Opitz trigonocephaly-like syndrome. The C-like syndrome seems to be a severe form of the C syndrome. It is controversial whether there is (1) a gradient of spectrum in the C syndrome, from the mild form (C syndrome) to the severe form (C-like syndrome), or (2) genetic heterogeneity among the patients with the C syndrome.
- Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
- Developmental stageExpressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus.
- Cellular localizationMembrane.
- CD96 antibodyCell surface antigen CD96 antibodyDKFZp667E2122 antibody
- MGC22596 antibodyT cell activated increased late expression protein antibodyT cell surface protein tactile antibodyT cell surface protein tactile precursor antibodyTACT_HUMAN antibodyTactile antibody
Anti-CD96 antibody images
Anti-CD96 antibody (ab128828) at 1 µg/ml + HeLa cell lysate at 10 µg
Predicted band size : 66 kDa
References for Anti-CD96 antibody (ab128828)
ab128828 has not yet been referenced specifically in any publications.