Anti-CD96 antibody (ab128828)

Overview

• Product nameAnti-CD96 antibodySee all CD96 primary antibodies ...
• Description
  Rabbit polyclonal to CD96
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide corresponding to a region within C-terminal amino acids 429-478 (TTPQPSNSSM TTRGFNYPWT SSGTDTKKSV SRIPSETYSS SPSGAGSTLH) of Human CD96 (NP_937839).

  Run BLAST with Run BLAST with
• Positive controlHeLa cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferConstituents: 97% PBS, 2% Sucrose
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Stem Cells
  • Cancer Stem Cells
  • Surface Molecules

  • Immunology
  • Adaptive Immunity
  • T Cells
  • CD

Applications

Target

• FunctionMay be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
• Tissue specificityExpressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
• Involvement in diseaseDefects in CD96 are a cause of C syndrome (CSYN) [MIM:211750]; also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. Note=A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
  Defects in CD96 are a cause of C-like syndrome (CLSYN) [MIM:605039]; also called Opitz trigonocephaly-like syndrome. The C-like syndrome seems to be a severe form of the C syndrome. It is controversial whether there is (1) a gradient of spectrum in the C syndrome, from the mild form (C syndrome) to the severe form (C-like syndrome), or (2) genetic heterogeneity among the patients with the C syndrome.
• Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 2 Ig-like V-type (immunoglobulin-like) domains.
• Developmental stageExpressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus.
• Cellular localizationMembrane.

Target information above from: UniProt accession P40200 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 10225 Human
  • Entrez Gene: 10225 Human
  • Omim: 606037 Human
  • SwissProt: P40200 Human
  • SwissProt: P40200 Human
  • Unigene: 142023 Human

• Alternative names
  CD96 antibodyCell surface antigen CD96 antibodyDKFZp667E2122 antibody

  MGC22596 antibodyT cell activated increased late expression protein antibodyT cell surface protein tactile antibodyT cell surface protein tactile precursor antibodyTACT_HUMAN antibodyTactile antibody

  see all

Anti-CD96 antibody images

• 

  Western blot - Anti-CD96 antibody (ab128828)
  Anti-CD96 antibody (ab128828) at 1 µg/ml + HeLa cell lysate at 10 µg
  
  Predicted band size : 66 kDa