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Products:Cardiovascular >> Blood >> Other
Overview
Product name
CDAN1 peptide
See all CDAN1 products (2) ...
Protein description
Synthetic peptide derived from within residues 1200 to the C-terminus of Human CDAN1.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab28932 - CDAN1 antibody..
Protein length
1227 amino acids
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
Concentration information loading...
Research areas
Cell Biology >> Other Antibodies >> Other Antibodies
Cardiovascular >> Blood >> Other
Applications
Protein info
Function
Might be involved in nuclear membrane integrity.
Tissue specificity
Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
Involvement in disease
Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1) [MIM:224120]. An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ8IWY9
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for CDAN1 peptide (ab28452)
ab28452 has not yet been referenced specifically in any publications.
Publishing research using ab28452? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"