Anti-CDC11 antibody (ab66452)

Relevance

CDC11 is a component of Septins. Septins are GTPases involved in cytokinesis. They assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence. This then transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins bind assymetrically to the septin collar. The septin assembly is regulated by protein kinases GIN4 and/or CLA4. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.

Cellular localization

Membrane. Bud neck. Note: Present at the bud neck during cell division.

Alternative names

Database links