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- Proteins and Peptides
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Product name
Anti-CED6 antibody
See all CED6 products (4) ...
Description
Goat polyclonal to CED6
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide: EGTVFCLDPLDSRC, corresponding to amino acids 291-304 of Human CED6.
EGTVFCLDPLDSRC
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris-saline. pH 7.3
Concentration
Concentration information loading...
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CED6 antibody (ab2751)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab2751 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
IHC-P
Application notes
Tested in peptide ELISA at 1:64000.
IHC-P: Use at a concentration of 5 µg/ml.
Western Blot: Preliminary experiments gave an approx 35kDa band in K562 lysates at 1µg/ml. However, this was accompanied by stronger bands at approx 45kDa and 48kDa. Please note that currently we cannot find an explanation in the literature for these extra bands given the predicted size of approx. 35kDda according to NP_057399.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Tissue specificity
Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
Sequence similarities
Belongs to the ced-6 family.
Contains 1 PID domain.
Cellular localization
Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Target information above from: UniProt accessionQ9UBP9
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CED6 antibody
- Cell death protein 6 homolog antibody
- Engulfment adapter protein antibody
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Database links
- Entrez Gene: 51454 Human
- Entrez Gene: 70676 Mouse
- Entrez Gene: 314543 Rat
- Omim: 608165 Human
- SwissProt: Q9UBP9 Human
- SwissProt: Q8K2A1 Mouse
- SwissProt: Q5PQS4 Rat
- Unigene: 470887 Human
see all
Anti-CED6 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CED6 antibody (ab2751)
ab2751 at 5ug/ml staining CED6 in human kidney tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). The AP-staining procedure was used for detection.
References for Anti-CED6 antibody (ab2751)
ab2751 has not yet been referenced specifically in any publications.
Publishing research using ab2751? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"