CETP antibody [2H6] - C-terminal (ab78164)

Product Name 

CETP antibody [2H6] - C-terminal

Product type 

Primary antibodies

Description 

Mouse monoclonal [2H6] to CETP - C-terminal

Immunogen 

Synthetic peptide: EHLLVDFLQSLS, corresponding to C terminal amino acids 482-493 of Human CETP
BLAST 'EHLLVDFLQSLS' with or

Reacts with 

Hu

Predicted to react 
(species key)

CynMk
(Due to sequence homology)

Tested applications 
(see key)

ELISA, ICC/IF, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: 1/500 - 1/5000.
ICC/IF: 1/500 - 1/5000.
WB: 1/500 - 1/5000 on endogenous and recombinant protein. Predicted molecular weight: 55 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Atherosclerosis >> Lipid transport
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism

Relevance 

High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

2H6

Isotype 

IgG1

Purity 

Ascites

Storage buffer 

Preservative: None
Constituents: Ascites

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

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