CETP antibody [ATM192] (ab2726)

Product Name 

CETP antibody [ATM192]

Product type 

Primary antibodies

Description 

Mouse monoclonal [ATM192] to CETP

Immunogen 

Synthetic peptide: (131)CDSGR VRTDAPD(14 2)
Immu peptide corresponds to the C-terminal amino acid residues 131-142 of the human CETP protein.
BLAST 'CDSGRVRTDAPD' with or

Reacts with 
(species key)

Hu, Rb

Specificity 

Detects cholesteryl ester transfer protein (CETP) from human and rabbit tissues.

Tested applications 
(see key)

ELISA, IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution. Use protein G beads.
WB: 1/400. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

WB,IP: human serum
WB: human liver lysate

Cellular localization 

Secreted

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cardiovascular >> Atherosclerosis >> Lipid transport
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism

Relevance 

High density lipoproteins (HDLs) have been proposed to function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

ATM192

Isotype 

IgG1

Purity 

Protein A purified

Storage buffer 

PBS with 0.05% sodium azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Purified from ascites.

Form 

Liquid

Concentration 

2.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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CETP antibody [ATM192] images:

References for CETP antibody [ATM192] (ab2726)

  This product has been used in:

Thomas AP et al. Mouse monoclonal antipeptide antibodies specific for cholesteryl ester transfer protein (CETP). Hybridoma 15:359-64 (1996). PubMed: 8913785
If you publish research using ab2726 please let us know so that we can cite the reference on this datasheet.

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