Anti-CFHR5 antibody (ab118122)

Overview

• Product nameAnti-CFHR5 antibodySee all CFHR5 primary antibodies ...
• Description
  Rabbit polyclonal to CFHR5
• Tested applicationsWB, IP more details
• Species reactivity
  Reacts with: Recombinant Fragment
  Predicted to work with: Human
• Immunogen

  Recombinant full length protein, corresponding to amino acids 1-569 of Human CFHR5 (NP_110414.1).

• Positive controlCFHR5 transfected 293T cell line.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferConstituent: 99% Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Immunology
  • Innate Immunity
  • Complement
  • Regulatory

  • Immunology
  • Innate Immunity
  • Complement
  • Alternative Pathway

Applications

Target

• FunctionInvolved in complement regulation.
• Tissue specificityExpressed by the liver and secreted in plasma.
• Involvement in diseaseNote=Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
• Sequence similaritiesContains 9 Sushi (CCP/SCR) domains.
• Cellular localizationSecreted.

Target information above from: UniProt accession Q9BXR6 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 81494 Human
  • Entrez Gene: 81494 Human
  • Omim: 608593 Human
  • SwissProt: Q9BXR6 Human
  • SwissProt: Q9BXR6 Human
  • Unigene: 282594 Human

• Alternative names
  CFHL5 antibodyCFHR5 antibodyComplement factor H-related protein 5 antibody

  factor H-related protein 5 antibodyFHR-5 antibodyFHR5 antibodyFHR5_HUMAN antibodyFLJ10549 antibodyMGC133240 antibodyOTTHUMP00000034672 antibody

  see all

Anti-CFHR5 antibody images

• 

  Western blot - Anti-CFHR5 antibody (ab118122)
  All lanes : Anti-CFHR5 antibody (ab118122) at 1/1000 dilution
  
  Lane 1 : 293T cell line, transfected with CFHR5
  Lane 2 : 293T cell line, non-transfected
  
  Lysates/proteins at 25 µg per lane.
  
  
  Predicted band size : 64 kDa
  
• 

  Immunoprecipitation - Anti-CFHR5 antibody (ab118122)
  Immunoprecipitation of CFHR5 transfected lysate using ab118122 antibody and Protein A Magnetic Beads, immunoblotted with ab118122.