Anti-CFTR antibody (ab59394)
- Product nameAnti-CFTR antibodySee all CFTR primary antibodies ...
- DescriptionRabbit polyclonal to CFTR
- SpecificityThis antibody detects endogenous levels of total CFTR protein.
- Tested applicationsELISA, IHC-P more details
- Species reactivityReacts with: Mouse, Human
Synthesized non-phosphopeptide derived from human CFTR around the phosphorylation site of serine 737.
- Positive control
- IHC-P: Human colon carcinoma tissue.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab59394 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||IHC-P: 1/50 - 1/100.|
- FunctionInvolved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.
- Tissue specificityFound on the surface of the epithelial cells that line the lungs and other organs.
- Involvement in diseaseDefects in CFTR are the cause of cystic fibrosis (CF) [MIM:219700]; also known as mucoviscidosis. CF is the most common genetic disease in the Caucasian population, with a prevalence of about 1 in 2'000 live births. Inheritance is autosomal recessive. CF is a common generalized disorder of exocrine gland function which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes.
Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD) [MIM:277180]. CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
- Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.
- DomainThe PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex.
modificationsPhosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites.
Ubiquitinated, leading to its degradation in the lysosome. Deubiquitination by USP10 in early endosomes, enhances its endocytic recycling.
- Cellular localizationEarly endosome membrane.
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- ABCC7 antibody
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- ATP Binding Cassette Superfamily C Member 7 antibody
- ATP binding cassette transporter sub family C member 7 antibody
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Anti-CFTR antibody images
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using ab59394 at a 1/50 dilution.
Left image: un-treated.
Right image: treated with peptide.
References for Anti-CFTR antibody (ab59394)
ab59394 has not yet been referenced specifically in any publications.