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CGP 57380

Product code: ab120365 (formerly Asc-365)

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Overview

Product name

CGP 57380

Description

MNK inhibitor

Biological description

Low-molecular-weight kinase inhibitor of of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 µM respectively). Inhibits a range of other kinases (IC50 values in µM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5).

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

N-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine

Molecular Weight

244.23

Chemical structure

Chemical Structure

Molecular formula

C11H9FN6

CAS Number

522629-08-9

Solubility

Soluble in DMSO to 100 mM

Storage instructions

Store at +4°C.

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Kinase >> MNK >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> General
Biochemicals >> Chemical Type >> Biochemicals

References for CGP 57380 (ab120365)

This product has been referenced in:

  • Bain J  et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
  • Knauf U  et al. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol Cell Biol 21:5500-11 (2001).Read more (PubMed: 11463832) »

See all 3 publications for this product

Publishing research using ab120365? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"