Overview

  • Product name
    CHIR 98014
  • Description
    Potent, selective ATP-competitive GSK3 inhibitor
  • Biological description
    Potent, selective ATP-competitive GSK3 inhibitor (IC50 values are 0.58 and 0.65 nM for GSKα and GSKβ respectively). Potently activates the Wnt/beta-catenin signaling pathway. Also supplied as solution (ab146633).
  • Purity
    > 98%

Properties

  • Chemical name
    N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine
  • Molecular weight
    486.32
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H17Cl2N9O2
  • CAS Number
    556813-39-9
  • PubChem identifier
    53396311
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N
  • Source

    Synthetic

  • Research areas

    References for CHIR 98014 (ab146582)

    This product has been referenced in:
    • Naujok O  et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes 7:273 (2014). Read more (PubMed: 24779365) »
    • Selenica ML  et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol 152:959-79 (2007). Read more (PubMed: 17906685) »
    • Ring DB  et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52:588-95 (2003). Read more (PubMed: 12606497) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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