Anti-CHMP2A antibody (ab118729)

Overview

• Product nameAnti-CHMP2A antibodySee all CHMP2A primary antibodies ...
• Description
  Rabbit polyclonal to CHMP2A
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide corresponding to a region within C terminal amino acids 169-218 (DELGLSLTDE LSNLPSTGGS LSVAAGGKKA EAAASALADA DADLEERLKN) of Human CHMP2A (NP_055268).

  Run BLAST with Run BLAST with
• Positive control293T cell lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferConstituents: 97% PBS, 2% Sucrose
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Trafficking
  • Organelle Proteins

Applications

Target

• FunctionProbable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
• Sequence similaritiesBelongs to the SNF7 family.
• DomainThe acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
• Cellular localizationLate endosome membrane. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Target information above from: UniProt accession O43633 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 27243 Human
  • Omim: 610893 Human
  • SwissProt: O43633 Human
  • Unigene: 12107 Human

• Alternative names
  BC2 antibodyCharged multivesicular body protein 2a antibodyCHM2A_HUMAN antibody

  CHMP2 antibodyCHMP2a antibodyChromatin modifying protein 2a antibodyChromatin-modifying protein 2a antibodyhVps2 1 antibodyhVps2-1 antibodyputative breast adenocarcinoma marker antibodyPutative breast adenocarcinoma marker BC-2 antibodyPutative breast adenocarcinoma marker BC2 antibodyVacuolar protein sorting associated protein 2 1 antibodyVacuolar protein sorting-associated protein 2-1 antibodyVps2 1 antibodyVPS2 antibodyVps2-1 antibodyVPS2A antibody

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Anti-CHMP2A antibody images

• 

  Western blot - Anti-CHMP2A antibody (ab118729)
  Anti-CHMP2A antibody (ab118729) at 1 µg/ml + 293T cell lysate at 10 µg
  
  Predicted band size : 25 kDa