Overview
- Product nameAnti-CHRDL1 antibody [3H1-F6-A10 ]See all CHRDL1 primary antibodies ...
- DescriptionMouse monoclonal [3H1-F6-A10 ] to CHRDL1
- Specificityab131189 detects endogenous levels of CHRDL1 and does not cross react with related proteins.
- Tested applicationsICC/IF, WB, ELISA more details
- Species reactivityReacts with: Rat, Human
- Immunogen
Purified recombinant Human CHRDL1 fragments expressed in E.coli.
- Positive controlRat kidney tissue lysate
Properties
- FormLiquid
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferpH: 7.40
Preservative: 0.2% Sodium azide
Constituents: 49% Tris glycine, 50% Glycerol, 0.88% Sodium chloride -
Concentration information loading... - PurityProtein G purified
- Clonality Monoclonal
- Clone number3H1-F6-A10
- IsotypeIgG1
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab131189 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ICC/IF | ICC/IF: Use at an assay dependent concentration. |
| WB | WB: 1/1000. Predicted molecular weight: 51 kDa. |
| ELISA | ELISA: Use at an assay dependent dilution. |
Target
- FunctionAntagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.
- Tissue specificityExpressed in retinal pericytes.
- Sequence similaritiesContains 3 VWFC domains.
- Cellular localizationSecreted.
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Database links
- Entrez Gene: 91851 Human
- Entrez Gene: 91851 Human
- Entrez Gene: 91851 Human
- Entrez Gene: 363455 Rat
- Omim: 300350 Human
- SwissProt: Q9BU40 Human
- SwissProt: Q9BU40 Human
- SwissProt: Q9BU40 Human
- SwissProt: Q76LD0 Rat
- Unigene: 496587 Human
- Unigene: 211154 Rat
see all
Target information above from: UniProt accession
Q9BU40
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- CHL antibodychordin like 1 antibodyChordin-like protein 1 antibody
- CHRDL1 antibodyCRDL1_HUMAN antibodydA141H5.1 antibodyneuralin 1 antibodyNeuralin-1 antibodyNeurogenesin-1 antibodyNRLN1 antibodyVentroptin antibodyVOPT antibody
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Anti-CHRDL1 antibody [3H1-F6-A10 ] images
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![Western blot - Anti-CHRDL1 antibody [not given] (ab131189)](http://a.abcam.com/ps/datasheet/images/131/ab131189/CHRDL1-Primary-antibodies-ab131189-1.jpg)
Western blot - Anti-CHRDL1 antibody [not given] (ab131189)Anti-CHRDL1 antibody [3H1-F6-A10 ] (ab131189) at 1/1000 dilution + Rat kidney tissue lysate
Predicted band size : 51 kDa -
![Immunocytochemistry/ Immunofluorescence - Anti-CHRDL1 antibody [3H1-F6-A10 ] (ab131189)](http://a.abcam.com/ps/datasheet/images/131/ab131189/CHRDL1-Primary-antibodies-ab131189-2.jpg)
Immunocytochemistry/ Immunofluorescence - Anti-CHRDL1 antibody [3H1-F6-A10 ] (ab131189)Immunocytochemistry stain of Hela cells using ab131189(1:300).
References for Anti-CHRDL1 antibody [3H1-F6-A10 ] (ab131189)
ab131189 has not yet been referenced specifically in any publications.
