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Product name
CIB1 protein (His tag)
See all CIB1 products (3) ...
Protein description
Recombinant CIB1 fusion protein. Fusion: His-Tag at N-terminus.
Expression host
E. coli
Properties
Purity
> 95% by SDS-PAGE
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.002% Sodium Azide
Constituents: 3mM Sodium chloride, 2.5mM Imidazole, 10mM Tris, pH 8.0
Concentration
Concentration information loading...
Research areas
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Binding Proteins
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Beta
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Integrins >> Alpha
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SDS-PAGE - CIB1 protein (ab40628)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab40628 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
SDS-PAGE
Application notes
SDS-PAGE : Use at an assay dependent dilution.
Mass Spectrometry : Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
Tissue specificity
Ubiquitous.
Sequence similarities
Contains 2 EF-hand domains.
Cellular localization
Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
Target information above from: UniProt accessionQ99828
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
CIB1 protein (His tag) images:
SDS-PAGE - CIB1 protein (ab40628)
Analysis of CIB1 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining.
References for CIB1 protein (His tag) (ab40628)
ab40628 has not yet been referenced specifically in any publications.
Publishing research using ab40628? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"