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Anti-CISH antibody (ab5923)

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Overview

Product name

Anti-CISH antibody
See all CISH products (2) ...

Description

Rabbit polyclonal to CISH

Tested applications

ELISA, WB, IPmore details

Cross reactivity

Reacts with

Mouse

Predicted to work with

Rat, Human

Immunogen

Synthetic peptide, corresponding to amino acids 170-185 of CIS-1

Positive control

Mouse embryo lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Primary antibody notes

This product is raised against Cis-1.

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab5923 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Tissue specificity

Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Contains 1 SH2 domain.
Contains 1 SOCS box domain.

Post-translational
modifications

Association with EPOR may target the protein for proteolysis by the ubiquitin-dependent proteasome pathway. CIS is mainly monubiquitinated (37 kDa form) but may also exist in a polyubiquitinated form (45 kDa).

Target information above from: UniProt accessionQ9NSE2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • cis 1 antibody
  • CIS antibody
  • CIS-1 antibody
  • CIS1 antibody
  • CISH antibody
  • CISH_HUMAN antibody
  • Cytokine inducible inhibitor of signaling type 1B antibody
  • Cytokine inducible SH2 containing protein antibody
  • Cytokine-inducible SH2-containing protein antibody
  • G18 antibody
  • Protein G18 antibody
  • SOCS antibody
  • Suppressor of cytokine signaling antibody
see all

References for Anti-CISH antibody (ab5923)

ab5923 has not yet been referenced specifically in any publications.

Publishing research using ab5923? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"