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Anti-CLEC9A antibody [8F9] (ab104910)

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Overview

Product name

Anti-CLEC9A antibody [8F9]
See all CLEC9A products (6) ...

Description

Mouse monoclonal [8F9] to CLEC9A

Tested applications

Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

RBL-2H3 cells expressing Human CLEC9A fused to an HA epitope

General notes

Growth Conditions: RPMI + 10% FCS + Pen + Strep + Glutamine + 2-ME.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

8F9

Myeloma

Sp2/0-Ag14

Isotype

IgG2a

Research areas

Immunology >> Innate Immunity >> Myeloid Cells
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules

Applications

Show applications key

Our Abpromise guarantee covers the use of ab104910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    Flow Cyt

     Flow Cyt: Use at an assa...Read more →

    Flow Cyt: Use at an assay dependent dilution. Block Fc receptor prior to staining to reduce background.

Target

Function

Functions as an endocytic receptor on a small subset of myeloid cells and induces intracellular signaling via spleen tyrosine kinase (Syk). Acts as a receptor for necrotic cells and can mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Tissue specificity

In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

Sequence similarities

Contains 1 C-type lectin domain.

Post-translational
modifications

N-glycosylated.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ6UXN8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • C type lectin domain family 9, member A antibody
  • C-type lectin domain family 9 member A antibody
  • CLC9A_HUMAN antibody
  • CLEC9A antibody
  • DNGR1 antibody
  • HEEE9341 antibody
  • UNQ9341 antibody
see all

Database links

References for Anti-CLEC9A antibody [8F9] (ab104910)

This product has been referenced in:

  • Sancho D  et al. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest 118:2098-110 (2008). Human.Read more (PubMed: 18497879) »

See 1 publication for this product

Publishing research using ab104910? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"