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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other
Overview
Product name
COMT peptide (52-65)
See all COMT products (3) ...
Protein description
Synthetic peptide: GDTKEQRILNHVLQ-C, corresponding to internal sequence amino acids 52-65 of Human COMT
This peptide was used as an immunogen for ab36144 - COMT antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Concentration
Concentration information loading...
Sequence
GDTKEQRILN HVLQ-C
Research areas
Signal Transduction >> Metabolism >> Drug metabolism
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Other
Protein info
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Tissue specificity
Brain, liver, placenta, lymphocytes and erythrocytes.
Sequence similarities
Belongs to the mammalian catechol-O-methyltransferase family.
Post-translational
modifications
The N-terminus is blocked.
Cellular localization
Cytoplasm and Cell membrane.
Target information above from: UniProt accessionP21964
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for COMT peptide (52-65) (ab45665)
ab45665 has not yet been referenced specifically in any publications.
Publishing research using ab45665? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"