Anti-COX1 / Cyclooxygenase 1 antibody (ab22720)

Overview

• Product nameAnti-COX1 / Cyclooxygenase 1 antibodySee all COX1 / Cyclooxygenase 1 primary antibodies ...
• Description
  Goat polyclonal to COX1 / Cyclooxygenase 1
• Specificityab22720 reacts with Prostaglandin H Synthase-1 (PGHS-1, Cox-1).
• Tested applicationsIHC-P, WB more details
• Species reactivity
  Reacts with: Mouse, Rat, Sheep, Human
  
• Immunogen

  Full length native protein (purified) (Sheep). Purified Sheep Cox-1

Properties

• FormLiquid
• Storage instructionsAliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipoprotein metabolism

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Types of disease
  • Heart disease

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Signal Transduction
  • Signaling Pathway
  • Lipid Signaling
  • Prostaglandins

  • Cardiovascular
  • Atherosclerosis
  • Lipoprotein metabolism

  • Cardiovascular
  • Blood
  • Platelets

  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

Applications

Target

• FunctionMay play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
• PathwayLipid metabolism; prostaglandin biosynthesis.
• Sequence similaritiesBelongs to the prostaglandin G/H synthase family.
  Contains 1 EGF-like domain.
• Cellular localizationMicrosome membrane. Endoplasmic reticulum membrane.

Target information above from: UniProt accession P23219 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5742 Human
  • Entrez Gene: 5742 Human
  • Entrez Gene: 5742 Human
  • Entrez Gene: 19224 Mouse
  • Entrez Gene: 24693 Rat
  • Omim: 176805 Human
  • SwissProt: P23219 Human
  • SwissProt: P23219 Human

  • SwissProt: P23219 Human
  • SwissProt: P22437 Mouse
  • SwissProt: Q63921 Rat
  • SwissProt: P05979 Sheep
  • Unigene: 201978 Human
  • Unigene: 275434 Mouse
  • Unigene: 44404 Rat

  see all

• Alternative names
  COX 1 antibodyCOX 3 antibodyCOX-1 antibody

  COX1 antibodyCOX3 antibodyCOX3 antibodyCyclooxygenase 1 antibodyCyclooxygenase 3, included antibodyCyclooxygenase-1 antibodyCyclooxygenase1 antibodyEC 1.14.99.1 antibodyPartial COX1 proteins, included antibodyPCOX 1 antibodyPCOX1 antibodyPCOX1 antibodyPGG/HS antibodyPGG/HS antibodyPGH synthase 1 antibodyPGH1_HUMAN antibodyPGHS 1 antibodyPGHS-1 antibodyPGHS1 antibodyPGHS1 antibodyPHS 1 antibodyPHS1 antibodyPHS1 antibodyProstaglandin endoperoxide synthase 1 antibodyProstaglandin endoperoxide synthase 1 antibodyProstaglandin G/H synthase 1 antibodyProstaglandin G/H synthase and cyclooxygenase antibodyProstaglandin G/H synthase and cyclooxygenase antibodyProstaglandin H Synthase 1 antibodyProstaglandin H2 synthase 1 antibodyProstaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibodyProstaglandin-endoperoxide synthase 1 antibodyPTGHS antibodyPTGHS antibodyPTGS 1 antibodyPTGS1 antibodyPTGS1 antibody

  see all

Anti-COX1 / Cyclooxygenase 1 antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX1 / Cyclooxygenase 1 antibody (ab22720)
  IHC image of ab22720 staining in human breast carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond^TM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab22720, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
  
  For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.