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Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Anti-COX1 / Cyclooxygenase 1 antibody
See all COX1 / Cyclooxygenase 1 products (15) ...
Description
Goat polyclonal to COX1 / Cyclooxygenase 1
Specificity
ab22720 reacts with Prostaglandin H Synthase-1 (PGHS-1, Cox-1).
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Sheep, Human
Immunogen
Full length native protein (purified) (Sheep). Purified Sheep Cox-1
Properties
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: Whole serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Blood >> Platelets
Immunology >> Innate Immunity >> Macrophage / Inflamm.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX1 / Cyclooxygenase 1 antibody (ab22720)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab22720 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
IHC-P
WB
Application notes
IHC-P: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 69 kDa. Dilution optimised using Chromogenic detection. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Function
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.
Cellular localization
Microsome membrane. Endoplasmic reticulum membrane.
Target information above from: UniProt accessionP23219
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- COX 1 antibody
- COX 3 antibody
- COX-1 antibody
see all
Database links
- Entrez Gene: 5742 Human
- Entrez Gene: 19224 Mouse
- Entrez Gene: 24693 Rat
- Omim: 176805 Human
- SwissProt: P23219 Human
- SwissProt: P22437 Mouse
- SwissProt: Q63921 Rat
- SwissProt: P05979 Sheep
see all
Anti-COX1 / Cyclooxygenase 1 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX1 / Cyclooxygenase 1 antibody (ab22720)
IHC image of ab22720 staining in human breast carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab22720, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
References for Anti-COX1 / Cyclooxygenase 1 antibody (ab22720)
ab22720 has not yet been referenced specifically in any publications.
Publishing research using ab22720? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"