Anti-COX1 / Cyclooxygenase 1 antibody (ab2338)

Overview

• Product nameAnti-COX1 / Cyclooxygenase 1 antibodySee all COX1 / Cyclooxygenase 1 primary antibodies ...
• Description
  Goat polyclonal to COX1 / Cyclooxygenase 1
• SpecificityThis antibody is expected to recognise both human isoforms of this protein.
• Tested applicationsWB, ELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide: QDDGPAVERPSTEL, corresponding to C terminal amino acids 586-599 of Human COX1 / Cyclooxygenase 1.

  Run BLAST with Run BLAST with
• General notesPrincipal Names – PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); COX1; PHS 1; PTGHS; PGG/HS; PGHS-1; prostaglandin G/H synthase and cyclooxygenase; COX3; PCOX1 Official Gene Symbol - PTGS1 GenBank Accession Number – NP_000953; NP_542158 LocusLink ID - 5742 Gene Ontology terms - Lipid metabolism; physiological processes; prostaglandin-endoperoxide synthase

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• PurityIgG fraction
• Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipoprotein metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Signal Transduction
  • Signaling Pathway
  • Lipid Signaling
  • Prostaglandins

  • Cardiovascular
  • Atherosclerosis
  • Lipoprotein metabolism

  • Cardiovascular
  • Blood
  • Platelets

  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

Applications

Target

• FunctionMay play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
• PathwayLipid metabolism; prostaglandin biosynthesis.
• Sequence similaritiesBelongs to the prostaglandin G/H synthase family.
  Contains 1 EGF-like domain.
• Cellular localizationMicrosome membrane. Endoplasmic reticulum membrane.

Target information above from: UniProt accession P23219 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5742 Human
  • Entrez Gene: 5742 Human
  • Entrez Gene: 5742 Human
  • Omim: 176805 Human
  • SwissProt: P23219 Human
  • SwissProt: P23219 Human
  • SwissProt: P23219 Human
  • Unigene: 201978 Human

• Alternative names
  COX 1 antibodyCOX 3 antibodyCOX-1 antibody

  COX1 antibodyCOX3 antibodyCyclooxygenase 1 antibodyCyclooxygenase 3, included antibodyCyclooxygenase-1 antibodyCyclooxygenase1 antibodyEC 1.14.99.1 antibodyPartial COX1 proteins, included antibodyPCOX 1 antibodyPCOX1 antibodyPGG/HS antibodyPGH synthase 1 antibodyPGH1_HUMAN antibodyPGHS 1 antibodyPGHS-1 antibodyPGHS1 antibodyPHS 1 antibodyPHS1 antibodyProstaglandin endoperoxide synthase 1 antibodyProstaglandin G/H synthase 1 antibodyProstaglandin G/H synthase and cyclooxygenase antibodyProstaglandin H Synthase 1 antibodyProstaglandin H2 synthase 1 antibodyProstaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibodyProstaglandin-endoperoxide synthase 1 antibodyPTGHS antibodyPTGS 1 antibodyPTGS1 antibody

  see all

Anti-COX1 / Cyclooxygenase 1 antibody images

• 

  Western blot - COX1 / Cyclooxygenase 1 antibody (ab2338)
  Ab2338 staining (1µg/ml) of HeLa lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX1 / Cyclooxygenase 1 antibody (ab2338)
  ab2338 (3.8 µg/ml) staining COX1/cyclooxygenase 1 in paraffin-embedded Human heart myocardial fibers following steamed antigen retrieval with citrate buffer (pH 6).