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Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Anti-COX1 / Cyclooxygenase 1 antibody
See all COX1 / Cyclooxygenase 1 products (15) ...
Description
Goat polyclonal to COX1 / Cyclooxygenase 1
Specificity
This antibody is expected to recognise both human isoforms of this protein.
Tested applications
WB, ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: QDDGPAVERPSTEL, corresponding to C terminal amino acids 586-599 of Human COX1 / Cyclooxygenase 1.
C-QDDGPAVE RPSTEL
General notes
Principal Names – PTGS1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); COX1; PHS 1; PTGHS; PGG/HS; PGHS-1; prostaglandin G/H synthase and cyclooxygenase; COX3; PCOX1
Official Gene Symbol - PTGS1
GenBank Accession Number – NP_000953; NP_542158
LocusLink ID - 5742
Gene Ontology terms - Lipid metabolism; physiological processes; prostaglandin-endoperoxide synthase
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Blood >> Platelets
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2338 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 3 µg/ml.
ELISA
ELISA: 1/32000ELISA: 1/32000
IHC-P: Use a concentration of 3 - 5 µg/ml.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Target
Function
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.
Cellular localization
Microsome membrane. Endoplasmic reticulum membrane.
Target information above from: UniProt accessionP23219
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- COX 1 antibody
- COX 3 antibody
- COX-1 antibody
see all
Database links
- Entrez Gene: 5742 Human
- Omim: 176805 Human
- SwissProt: P23219 Human
- Unigene: 201978 Human
Anti-COX1 / Cyclooxygenase 1 antibody images:
Western blot - COX1 / Cyclooxygenase 1 antibody (ab2338)
Ab2338 staining (1µg/ml) of HeLa lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX1 / Cyclooxygenase 1 antibody (ab2338)
ab2338 (3.8 µg/ml) staining COX1/cyclooxygenase 1 in paraffin-embedded Human heart myocardial fibers following steamed antigen retrieval with citrate buffer (pH 6).
References for Anti-COX1 / Cyclooxygenase 1 antibody (ab2338)
ab2338 has not yet been referenced specifically in any publications.
Publishing research using ab2338? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"