|
|
|
|
|
Product Name
|
COX1 / Cyclooxygenase 1 antibody
|
| |
See all COX1 / Cyclooxygenase 1 antibodies (13)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Rabbit polyclonal to COX1 / Cyclooxygenase 1
|
|
Immunogen
|
Full length native protein (purified) (Sheep).
|
|
Reacts with
(species key)
|
Mamm, Shp
|
|
Tested applications
(see key)
|
ELISA, WB
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
ELISA: 1/100000.
WB: 1/100. Predicted molecular weight: 68 kDa.
These dilutions should yield a positive result with sheep PGH synthase.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Cellular localization
|
Cytoplasmic and Plasma membrane
|
|
Research areas
|
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Cell Biology >> Other Antibodies >> Oxidative Stress
Cardiovascular >> Angiogenesis >> Angiogenic Factors
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Blood >> Platelets
Immunology >> Innate Immunity >> Macrophage / Inflamm.
|
|
Relevance
|
Cyclooxygenase (COX), also known as Prostaglandin H2 synthase and Prostaglandin endoperoxide synthase, is a key enzyme in the of conversion arachidonic acid to Prostaglandin H2. Prostaglandin H2 is converted by other enzymes into inflammatory mediators prostaglandin (PG) D2, PGE2, PGF2a, PGI2 and Thromboxane A2. Thus, COX is a key enzyme in the production of inflammatory agents and is the target of intense research and drug discovery activities. There are two enzymes of COX, COX 1 and COX 2. COX 1 is constitutively produced in many (most) cell types. It is important in the gut for the production of prostaglandins, which inhibit gastric secretion. It can be induced in monocytes, macrophages and other cells. It is induced as part of the inflammatory response by IL 1beta and other cytokines. It is induced by growth factors such as EGF and PDGF. Expression is inhibited by glucocorticosteroids such as cortisol and dexamethasone. Lipopolysaccharide in bacterial infections induces COX 2. COX 2 is also found in elevated levels in synoviocytes from rheumatoid arthritis patients. The discomforts of inflammation such as pain and swelling are largely due to the action of prostaglandins produced by COX2.
|
|
|
COX1 / Cyclooxygenase 1 antibody (ab23858) |
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Rabbit
|
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Purity
|
Whole antiserum
|
|
Storage buffer
|
Preservative: 0.05% Sodium Azide
Constituents: Whole serum Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
|
|
Form
|
Liquid
|
|
Concentration
|
Concentration not determined - why is this?
|
|
Storage instructions
|
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this COX1 / Cyclooxygenase 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
| |
|
Search PubMed (MEDLINE) for references to COX1 / Cyclooxygenase 1
|
| |
COX1 / Cyclooxygenase 1 antibody - more information
|
Customer reviews (feedback) regarding COX1 / Cyclooxygenase 1 antibody |
Customer FAQs regarding COX1 / Cyclooxygenase 1 antibody |
Protocols for COX1 / Cyclooxygenase 1 antibody |
Price and availability of products related to COX1 / Cyclooxygenase 1 antibody |
| |
COX1 / Cyclooxygenase 1 antibody - related products:
|
|
|
| |
COX1 / Cyclooxygenase 1 antibody - other tools:
|
Contact Abcam with a Technical Enquiry about COX1 / Cyclooxygenase 1 antibody |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
