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Anti-COX1 / Cyclooxygenase 1 antibody (ab53766)

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Overview

Product name

Anti-COX1 / Cyclooxygenase 1 antibody
See all COX1 / Cyclooxygenase 1 products (15) ...

Description

Rabbit polyclonal to COX1 / Cyclooxygenase 1

Specificity

ab53766 detects endogenous levels of total COX1 / Cyclooxygenase 1 protein.

Tested applications

WB, IHC-P, ELISAmore details

Cross reactivity

Reacts with

Human, Pig

Immunogen

Synthetic peptide peptide derived from human COX1 / Cyclooxygenase 1.

Positive control

IHC-P: Human brain tissued WB: HuvEc cell extracts.

Properties

Form

Liquid

Storage instructions

Store at -20°C. Stable for 12 months at -20°C

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

ab53766 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Blood >> Platelets
Immunology >> Innate Immunity >> Macrophage / Inflamm.

  • Western blot - COX1 / Cyclooxygenase 1 antibody (ab53766)Western blot - COX1 / Cyclooxygenase 1 antibody (ab53766) image (enlarge)

  • Immunohistochemistry (Paraffin-embedded sections) - COX1 / Cyclooxygenase 1 antibody (ab53766)Immunohistochemistry (Paraffin-embedded sections) - COX1 / Cyclooxygenase 1 antibody (ab53766) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab53766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    WB

     WB: 1/500 - 1/1000.Detec...Read more →

    WB: 1/500 - 1/1000.Detects a band of approximately 69 kDa (predicted molecular weight: 69 kDa).

  • 1 Image

    IHC-P

     IHC-P: 1/50 - 1/100.

    IHC-P: 1/50 - 1/100.

  • ELISA

     ELISA: 1/40000

    ELISA: 1/40000

Target

Function

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Sequence similarities

Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.

Cellular localization

Microsome membrane. Endoplasmic reticulum membrane.

Target information above from: UniProt accessionP23219 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • COX 1 antibody
  • COX 3 antibody
  • COX-1 antibody
  • COX1 antibody
  • COX3 antibody
  • Cyclooxygenase 1 antibody
  • Cyclooxygenase 3, included antibody
  • Cyclooxygenase-1 antibody
  • Cyclooxygenase1 antibody
  • EC 1.14.99.1 antibody
  • Partial COX1 proteins, included antibody
  • PCOX 1 antibody
  • PCOX1 antibody
  • PGG/HS antibody
  • PGH synthase 1 antibody
  • PGH1_HUMAN antibody
  • PGHS 1 antibody
  • PGHS-1 antibody
  • PGHS1 antibody
  • PHS 1 antibody
  • PHS1 antibody
  • Prostaglandin endoperoxide synthase 1 antibody
  • Prostaglandin G/H synthase 1 antibody
  • Prostaglandin G/H synthase and cyclooxygenase antibody
  • Prostaglandin H Synthase 1 antibody
  • Prostaglandin H2 synthase 1 antibody
  • Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody
  • Prostaglandin-endoperoxide synthase 1 antibody
  • PTGHS antibody
  • PTGS 1 antibody
  • PTGS1 antibody
see all

Database links

Anti-COX1 / Cyclooxygenase 1 antibody images:

  Western blot - COX1 / Cyclooxygenase 1 antibody (ab53766)

Western blot - COX1 / Cyclooxygenase 1 antibody (ab53766)

All lanes : Anti-COX1 / Cyclooxygenase 1 antibody (ab53766) at 1/500 dilution

Lane 1 : HuvEc cell extract
Lane 2 : HuvEc cell extract with immunising peptide


Predicted band size : 69 kDa
Observed band size : 69 kDa

  Immunohistochemistry (Paraffin-embedded sections) - COX1 / Cyclooxygenase 1 antibody (ab53766)

Immunohistochemistry (Paraffin-embedded sections) - COX1 / Cyclooxygenase 1 antibody (ab53766)

ab53766, at 1/50 dilution, staining COX1 / Cyclooxygenase 1 in human brain tissue by Immunohistochemsitry in the absence (left image) or presence (right image) of the immunising peptide.

References for Anti-COX1 / Cyclooxygenase 1 antibody (ab53766)

This product has been referenced in:

  • Lin Jet al. Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension. Arterioscler Thromb Vasc Biol 29:1810-6 (2009). WB; Pig.Read more (PubMed: 19628782) »

See 1 publication for this product

Publishing research using ab53766? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"