Anti-COX1 / Cyclooxygenase 1 antibody (ab84602)

Overview

• Product nameAnti-COX1 / Cyclooxygenase 1 antibodySee all COX1 / Cyclooxygenase 1 primary antibodies ...
• Description
  Rabbit polyclonal to COX1 / Cyclooxygenase 1
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Human COX1 / Cyclooxygenase 1.

  Read Abcam's proprietary immunogen policy

  (Peptide available as ab93495.)

• Positive controlThis antibody gave a positive signal in the following human whole cell lysates: A431; HUVEC.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipoprotein metabolism

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Oxidative stress

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Signal Transduction
  • Signaling Pathway
  • Lipid Signaling
  • Prostaglandins

  • Cardiovascular
  • Atherosclerosis
  • Lipoprotein metabolism

  • Cardiovascular
  • Blood
  • Platelets

  • Immunology
  • Innate Immunity
  • Macrophage / Inflamm.

Applications

Target

• FunctionMay play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
• PathwayLipid metabolism; prostaglandin biosynthesis.
• Sequence similaritiesBelongs to the prostaglandin G/H synthase family.
  Contains 1 EGF-like domain.
• Cellular localizationMicrosome membrane. Endoplasmic reticulum membrane.

Target information above from: UniProt accession P23219 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 5742 Human
  • Entrez Gene: 5742 Human
  • Entrez Gene: 5742 Human
  • Omim: 176805 Human
  • SwissProt: P23219 Human
  • SwissProt: P23219 Human
  • SwissProt: P23219 Human
  • Unigene: 201978 Human

• Alternative names
  COX 1 antibodyCOX 3 antibodyCOX-1 antibody

  COX1 antibodyCox3 antibodyCyclooxygenase 1 antibodyCyclooxygenase 3, included antibodyCyclooxygenase-1 antibodyEC 1.14.99.1 antibodyPartial COX1 proteins, included antibodyPCOX1 antibodyPGG/HS antibodyPGH synthase 1 antibodyPGH1_HUMAN antibodyPGHS-1 antibodyPGHS1 antibodyPHS 1 antibodyPHS1 antibodyProstaglandin G/H synthase 1 antibodyProstaglandin H2 synthase 1 antibodyProstaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibodyProstaglandin-endoperoxide synthase 1 antibodyPTGHS antibodyPTGS1 antibody

  see all

Anti-COX1 / Cyclooxygenase 1 antibody images

• 

  Western blot - COX1 / Cyclooxygenase 1 antibody (ab84602)
  All lanes : Anti-COX1 / Cyclooxygenase 1 antibody (ab84602) at 1 µg/ml
  
  Lane 1 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
  Lane 2 : HUVEC (Human Umbilical Vein Endothelial Cell) Whole Cell Lysate
  
  Lysates/proteins at 10 µg per lane.
  
  Secondary
  Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
  developed using the ECL technique
  
  Performed under reducing conditions.
  
  Predicted band size : 68 kDa
  Observed band size : 71,73 kDa (why is the actual band size different from the predicted?)
  Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.
  
  Exposure time : 2 minutes