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Products:Cardiovascular >> Blood >> Platelets

Anti-COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)

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Overview

Product name

Anti-COX2 / Cyclooxygenase 2 antibody [SP21]
See all COX2 / Cyclooxygenase 2 products (18) ...

Description

Rabbit monoclonal [SP21] to COX2 / Cyclooxygenase 2

Tested applications

IHC-Pmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat

Immunogen

Synthetic peptide (Rat) (C terminal).

Positive control

Lung carcinoma, colon carcinoma and breast carcinoma; HT 29 lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: Tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

SP21

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Cancer >> Tumor biomarkers >> Other
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Cardiovascular >> Blood >> Platelets

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab16701 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    IHC-P

     IHC-P: 1/100Perform heat...Read more →

    IHC-P: 1/100Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Application notes

Is unsuitable for or WB.

Target

Function

Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Sequence similarities

Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.

Post-translational
modifications

S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561.

Cellular localization

Microsome membrane. Endoplasmic reticulum membrane.

Target information above from: UniProt accessionP35354 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • COX 2 antibody
  • COX-2 antibody
  • COX2 antibody
  • Cyclooxygenase 2 antibody
  • Cyclooxygenase 2b antibody
  • Cyclooxygenase antibody
  • Cyclooxygenase-2 antibody
  • Cyclooxygenase2 antibody
  • EC 1.14.99.1 antibody
  • fj02a10 antibody
  • Glucocorticoid-regulated inflammatory cyclooxygenase antibody
  • Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody
  • GRIPGHS antibody
  • hCox 2 antibody
  • Macrophage activation-associated marker protein P71/73 antibody
  • OTTHUMP00000033524 antibody
  • PES-2 antibody
  • PGG/HS antibody
  • PGH synthase 2 antibody
  • PGH2_HUMAN antibody
  • PGHS 2 antibody
  • PGHS-2 antibody
  • PGHS2 antibody
  • PHS 2 antibody
  • PHS II antibody
  • PHS2 antibody
  • Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody
  • Prostaglandin endoperoxide synthase 2 antibody
  • Prostaglandin G/H synthase 2 antibody
  • Prostaglandin G/H synthase 2 precursor antibody
  • Prostaglandin G/H synthase and cyclooxygenase antibody
  • Prostaglandin G/H synthase antibody
  • Prostaglandin H2 synthase 2 antibody
  • Prostaglandin-endoperoxide synthase 2 antibody
  • PTGS2 antibody
  • ptgs2a antibody
  • TIS10 antibody
  • TIS10 protein antibody
  • unp1239 antibody
  • wu:fj02a10 antibody
see all

Database links

see all

Anti-COX2 / Cyclooxygenase 2 antibody [SP21] images:

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)

ab16701 at 1/100 dilution staining COX2 / Cyclooxygenase 2 in human breast carcinoma by Immunohistochemistry (FFPE-sections).

References for Anti-COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)

This product has been referenced in:

  • Fujita Met al. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells. Cancer Res 71:2664-74 (2011).Read more (PubMed: 21324923) »
  • Lu TCet al. Analgesic and Anti-Inflammatory Activities of the Methanol Extract from Pogostemon cablin. Evid Based Complement Alternat Med : (2009).Read more (PubMed: 19933324) »

See all 2 publications for this product

Publishing research using ab16701? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"