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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)](/ps/datasheet/images/ab16701_1.jpg)
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Product Name
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COX2 / Cyclooxygenase 2 antibody [SP21]
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See all COX2 / Cyclooxygenase 2 antibodies (16)...
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Product type
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Primary antibodies
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Description
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Rabbit monoclonal [SP21] to COX2 / Cyclooxygenase 2
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Immunogen
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Synthetic peptide (Rat) (C terminal).
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Reacts with
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Hu
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Predicted to react
(species key)
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Ms, Rat
(Due to sequence homology)
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Tested applications
(see key)
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IHC-P
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Lung carcinoma, colon carcinoma and breast carcinoma; HT 29 lysate.
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Cellular localization
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Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Cancer >> Tumor biomarkers >> Other
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Cardiovascular >> Blood >> Platelets
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Relevance
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COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Monoclonal
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Clone number
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SP21
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Isotype
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IgG
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Purity
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Tissue culture supernatant
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: Tissue culture supernatant Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this COX2 / Cyclooxygenase 2 antibody [SP21] is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for COX2 / Cyclooxygenase 2 antibody [SP21] images, references, products related to ab16701 and other tools.
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COX2 / Cyclooxygenase 2 antibody [SP21] images:
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 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)
ab16701 at 1/100 dilution staining COX2 / Cyclooxygenase 2 in human breast carcinoma by Immunohistochemistry (FFPE-sections).
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References for COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)
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This product has been used in:
Lu TC et al. Analgesic and Anti-Inflammatory Activities of the Methanol Extract from Pogostemon cablin. Evid Based Complement Alternat Med : (2009). PubMed: 19933324
If you publish research using ab16701 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to COX2 / Cyclooxygenase 2
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COX2 / Cyclooxygenase 2 antibody [SP21] - more information
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Customer reviews (feedback) regarding COX2 / Cyclooxygenase 2 antibody [SP21] |
Customer FAQs regarding COX2 / Cyclooxygenase 2 antibody [SP21] |
Protocols for COX2 / Cyclooxygenase 2 antibody [SP21] |
Price and availability of products related to COX2 / Cyclooxygenase 2 antibody [SP21] |
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COX2 / Cyclooxygenase 2 antibody [SP21] - related products:
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COX2 / Cyclooxygenase 2 antibody [SP21] - other tools:
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Contact Abcam with a Technical Enquiry about COX2 / Cyclooxygenase 2 antibody [SP21] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - COX2 / Cyclooxygenase 2 antibody [SP21] (ab16701)](/index.html?datasheet=16701#ab16701_1.jpg)
