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Products:Cardiovascular >> Blood >> Platelets
Overview
Product name
Anti-COX2 / Cyclooxygenase 2 antibody
See all COX2 / Cyclooxygenase 2 products (18) ...
Description
Rabbit polyclonal to COX2 / Cyclooxygenase 2
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide (Human)
Positive control
Extracts from A549 cells.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Cardiovascular >> Atherosclerosis >> Lipoprotein metabolism
Cancer >> Tumor biomarkers >> Other
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Prostaglandins
Cardiovascular >> Lipids / Lipoproteins >> Lipid Metabolism >> Cholesterol Metabolism
Cardiovascular >> Blood >> Platelets
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Western blot - COX2 / Cyclooxygenase 2 antibody (ab52237)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab52237 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/20,000ELISA: 1/20,000
WB: 1/300 - 1/1000.Detects a band of approximately 69 kDa (predicted molecular weight: 69 kDa).
Target
Function
Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.
Post-translational
modifications
S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561.
Cellular localization
Microsome membrane. Endoplasmic reticulum membrane.
Target information above from: UniProt accessionP35354
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- COX 2 antibody
- COX-2 antibody
- COX2 antibody
see all
Database links
- Entrez Gene: 5743 Human
- Entrez Gene: 19225 Mouse
- Entrez Gene: 29527 Rat
- Omim: 600262 Human
- SwissProt: P35354 Human
- SwissProt: Q05769 Mouse
- SwissProt: P35355 Rat
- Unigene: 196384 Human
see all
Anti-COX2 / Cyclooxygenase 2 antibody images:
Western blot - COX2 / Cyclooxygenase 2 antibody (ab52237)
Anti-COX2 / Cyclooxygenase 2 antibody (ab52237) (Human mesothelioma whole cell lysate.)
Secondary
Goat anti-rabbit HRP
Predicted band size : 69 kDa
Please see accompanying abreview for additional information
This image is courtesy of an anonymous Abreview
References for Anti-COX2 / Cyclooxygenase 2 antibody (ab52237)
This product has been referenced in:
- Yang Let al. Biological Function and Prognostic Significance of Peroxisome Proliferator-Activated Receptor {delta} in Rectal Cancer. Clin Cancer Res 17:3760-70 (2011). WB; Human.Read more (PubMed: 21531809) »
- Zhu Xet al. Aldosterone stimulates superoxide production in macula densa cells. Am J Physiol Renal Physiol 301:F529-35 (2011). WB; Mouse.Read more (PubMed: 21270097) »
See all 5 publications for this product
Publishing research using ab52237? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"