Anti-CPI-17 antibody (ab131451)
Key features and details
- Rabbit polyclonal to CPI-17
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CPI-17 antibody
See all CPI-17 primary antibodies -
Description
Rabbit polyclonal to CPI-17 -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IFmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human CPI-17 aa 36-40 (internal sequence) conjugated to keyhole limpet haemocyanin.
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Positive control
- Methanol fixed HeLa cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
PBS without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab131451 was purified by affinity chromatography using epitope specific peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab131451 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
1/100 - 1/200.
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Notes |
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ICC/IF
1/100 - 1/200. |
Target
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Function
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. -
Tissue specificity
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta. -
Sequence similarities
Belongs to the PP1 inhibitor family. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 94274 Human
- Omim: 608153 Human
- SwissProt: Q96A00 Human
- Unigene: 631569 Human
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Alternative names
- 17 kDa PKC-potentiated inhibitory protein of PP1 antibody
- 17-KDa protein antibody
- 17kDa PKC potentiated inhibitory protein of PP1 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab131451 has been referenced in 1 publication.
- Chen J et al. Roles and mechanisms of TRPC3 and the PLC?/PKC/CPI-17 signaling pathway in regulating parturition. Mol Med Rep 17:898-910 (2018). PubMed: 29115500