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Products:Neuroscience >> Cell Type Marker >> Neuron marker >> Growth Cone
Overview
Product name
Anti-CRMP5 antibody [CR-1]
See all CRMP5 products (5) ...
Description
Rat monoclonal [CR-1] to CRMP5
Specificity
This anitbody is specific for the C terminal region. Not reactive with other CRMP isoforms.
Tested applications
IHC-Fr, WBmore details
Cross reactivity
Reacts with
Rat, Cow, Human
Immunogen
Purified protein from Human brain. This anitbody is specific for the C terminal region, amino acids 369-564.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Clone number
CR-1
Isotype
IgG1
Research areas
Neuroscience >> Neurology process >> Growth and Development >> Axonal Guidance Proteins
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Neuroscience >> Cell Type Marker >> Neuron marker >> Growth Cone
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19378 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr
WB
Application notes
IHC-Fr: 1/200.
WB: 1/2000. By Western blot, this antibody detects an ~ 62 kDa protein corresponding to human CRMP5 from brain extract.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.
Cellular localization
Cytoplasmic
Alternative names
- Collapsin response mediator protein 5 antibody
- CRAM antibody
- CRMP 3 associated molecule antibody
see all
Database links
- Entrez Gene: 100126171 Cow
- Entrez Gene: 56896 Human
- Entrez Gene: 65208 Rat
- Omim: 608383 Human
- SwissProt: Q9BPU6 Human
- SwissProt: Q9JHU0 Rat
- Unigene: 299315 Human
- Unigene: 44871 Rat
References for Anti-CRMP5 antibody [CR-1] (ab19378)
ab19378 has not yet been referenced specifically in any publications.
Publishing research using ab19378? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"