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Products:Neuroscience >> Cell Type Marker >> Neuron marker >> Growth Cone
Overview
Product name
Anti-CRMP5 antibody [CR-3]
See all CRMP5 products (5) ...
Description
Rat monoclonal [CR-3] to CRMP5
Specificity
Not reactive with other CRMP isoforms.
Tested applications
WB, IHC-Frmore details
Cross reactivity
Reacts with
Mouse, Rat, Cow, Human
Immunogen
Full length protein purified protein from human brain, corresponding to N terminal amino acids 1-64 of Human CRMP5.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: Ascites
Concentration
Concentration information loading...
Purity
Ascites
Clonality
Monoclonal
Clone number
CR-3
Isotype
IgG2a
Research areas
Neuroscience >> Neurology process >> Growth and Development >> Axonal Guidance Proteins
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Neuroscience >> Cell Type Marker >> Neuron marker >> Growth Cone
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19352 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/50 - 1/1000.Detects a band of approximately 62 kDa.
IHC-Fr
IHC-Fr: 1/50 - 1/400.IHC-Fr: 1/50 - 1/400.
Target
Relevance
The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.
Cellular localization
Cytoplasmic
Alternative names
- Collapsin response mediator protein 5 antibody
- CRAM antibody
- CRMP 3 associated molecule antibody
see all
Database links
- Entrez Gene: 100126171 Cow
- Entrez Gene: 56896 Human
- Entrez Gene: 65254 Mouse
- Entrez Gene: 65208 Rat
- Omim: 608383 Human
- SwissProt: Q9BPU6 Human
- SwissProt: Q9EQF6 Mouse
- SwissProt: Q9JHU0 Rat
see all
References for Anti-CRMP5 antibody [CR-3] (ab19352)
This product has been referenced in:
- Jiang SXet al. Calpain cleavage of collapsin response mediator proteins in ischemic mouse brain. Eur J Neurosci 26:801-9 (2007). WB; Mouse.Read more (PubMed: 17672855) »
See 1 publication for this product
Publishing research using ab19352? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"