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Products:Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Src Family
Overview
Product name
Anti-CSK antibody
See all CSK products (9) ...
Description
Rabbit polyclonal to CSK
Specificity
CSK polyclonal antibody detects total level of endogenous CSK protein.
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Chicken, Dog, Xenopus laevis, Zebrafish
Immunogen
Bacterially expressed recombinant protein: VVSEEPIYIV TEYMSKGSLL DFLKGETGKY LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS F, corresponding to C terminal amino acids 330-450 of CSK.
VVSEEPIYIV TEYMSKGSLL DFLKGETGKY LRLPQLV DMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVC KVADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS F
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
Purified from rabbit antisera by protein A affinity chromatography. Purity: > 95% (by SDS-PAGE)
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Src Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab21902 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 51 kDa.
Target
Function
Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.
Tissue specificity
Expressed in lung and macrophages.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.
Post-translational
modifications
Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.
Cellular localization
Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.
Target information above from: UniProt accessionP41240
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Tyrosine protein kinase CSK antibody
- zgc:154049 antibody
- C SRC antibody
see all
Database links
- Entrez Gene: 396396 Chicken
- Entrez Gene: 1445 Human
- Entrez Gene: 12988 Mouse
- Entrez Gene: 315707 Rat
- Entrez Gene: 373593 Xenopus laevis
- Entrez Gene: 556454 Zebrafish
- Omim: 124095 Human
- SwissProt: P00523 Chicken
see all
References for Anti-CSK antibody (ab21902)
ab21902 has not yet been referenced specifically in any publications.
Publishing research using ab21902? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"