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Anti-CSK antibody (ab54684)

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Overview

Product name

Anti-CSK antibody
See all CSK products (9) ...

Description

Mouse monoclonal to CSK

Tested applications

WB, IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant fragment: MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE , corresponding to amino acids 1-101 of Human CSK

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
PBS, pH 7.2

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Isotype

IgG1

Light chain type

kappa

  • IHC-P - CSK antibody (ab54684)IHC-P - CSK antibody (ab54684) image (enlarge)

  • Western blot - CSK antibody (ab54684)Western blot - CSK antibody (ab54684) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab54684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at a concentration of 1-5 µg/ml.
IHC-P: Use at a concentration of 1 µg/ml.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.

Tissue specificity

Expressed in lung and macrophages.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.

Post-translational
modifications

Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.

Cellular localization

Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.

Target information above from: UniProt accessionP41240 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Tyrosine protein kinase CSK antibody
  • zgc:154049 antibody
  • C SRC antibody
  • C SRC kinase antibody
  • C src Tyrosine Kinase antibody
  • C-SRC kinase antibody
  • Csk A antibody
  • CSK antibody
  • CSK_HUMAN antibody
  • EC 2.7.10.2 antibody
  • MGC112926 antibody
  • MGC117393 antibody
  • MGC154049 antibody
  • P60 Src antibody
  • Protein tyrosine kinase CYL antibody
  • Protein-tyrosine kinase CYL antibody
  • Proto oncogene tyrosine protein kinase antibody
  • Tyrosine-protein kinase CSK antibody
see all

Anti-CSK antibody images:

  IHC-P - CSK antibody (ab54684)

IHC-P - CSK antibody (ab54684)

CSK antibody (ab54684) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human colon.

  Western blot - CSK antibody (ab54684)

Western blot - CSK antibody (ab54684)

CSK antibody (ab54684) at 1ug/lane + HL-60 cell lysate at 25ug/lane.

References for Anti-CSK antibody (ab54684)

ab54684 has not yet been referenced specifically in any publications.

Publishing research using ab54684? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"