The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Predicted molecular weight: 21 kDa.
Use at an assay dependent concentration. PubMed: 18984963
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
Highly expressed in the aorta, but not in heart and skeletal muscle.
Tigerstedt NM et al. Mechanisms behind the synergistic effect of sirolimus and imatinib in preventing restenosis after intimal injury. J Vasc Res46:240-52 (2009).
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