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Read our guarantee »Products:Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
Anti-CTLA4 antibody [BNI3] - Azide free
See all CTLA4 products (20) ...
Mouse monoclonal [BNI3] to CTLA4 - Azide free
ICC, Flow Cyt, IHC-Frmore details
Reacts with
Human
Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig).
ICC/FACS: B cells
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Preservative: None
Constituents: PBS, 1mg/ml BSA. pH 7.2
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Immunogen affinity purified
Monoclonal
BNI3
P3x63-Ag8.653
IgG2a
Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Immunology >> Immune System Diseases >> Autoimmune
Immunology >> Adaptive Immunity >> T Cells >> CD
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
Our Abpromise guarantee covers the use of ab19792 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC: Use a concentration of 5 - 50 µg/ml.
Flow Cyt: Use at an assay dependent dilution. (Use 2µg for 5x 105 cells. )
IHC-Fr: Use a concentration of 5 - 50 µg/ml.
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12) [MIM:601388]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3) [MIM:609755]. It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
N-glycosylation is important for dimerization.
Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Cell membrane. Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation and.
Target information above from: UniProt accessionP16410
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
This product has been referenced in:
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