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Product Name
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CTLA4 antibody [BNI3] - Azide free
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See all CTLA4 antibodies (16)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [BNI3] to CTLA4 - Azide free
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Immunogen
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Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig).
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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Flow Cyt, ICC, IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use 2µg for 5x 105 cells.
ICC(IF): Use 2µg for 5x 105 cells.
IHC-Fr: Use at a concentration of 5 - 50 µg/ml.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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ICC/FACS: B cells
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Cellular localization
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Type I membrane protein.
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Research areas
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Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Immunology >> Immune System Diseases >> Autoimmune
Immunology >> Adaptive Immunity >> T Cells >> CD
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
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Relevance
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CTLA4 has a critical role in T cell differentiation and contributes to the maintenance of peripheral T cell tolerance to self antigens. It exerts its major effects on T cell immune responses via regulation of the cell cycle and may be involved in T cell activation. It binds to B7-1 (CD80) and B7-2 (CD86), and it contains one immunoglobulin-like V type domain. It is widely expressed, with highest levels in lymphoid tissues.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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BNI3
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Myeloma
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P3x63-Ag8.653
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Isotype
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IgG2a
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Purity
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Ascites
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Storage buffer
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Preservative: None
Constituents: PBS, 1mg/ml BSA. pH 7.2
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Form
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Liquid
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Concentration
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Batch dependent within range: 0.10 - 0.20 mg/ml
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Storage instructions
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Store at +4°C. Aliquot and store at -20°C or -80°C when reconstituted. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CTLA4 antibody [BNI3] - Azide free is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CTLA4
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