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Product Name
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CTLA4 antibody
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See all CTLA4 antibodies (16)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to CTLA4
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Immunogen
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Highly pure (>98%) recombinant mCTLA-4 (murine cytotoxic T lymphocyte associated antigen )
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Reacts with
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Ms
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Tested applications
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA:To detect mCTLA-4 by direct ELISA (using 100µl/well antibody solution) a concentration of at least 0.5µg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2 - 0.4 ng/well of recombinant mCTLA-4.
Western Blot:To detect mCTLA-4 by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant mCTLA-4 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
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Cellular localization
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Type I membrane protein.
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Research areas
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Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Immunology >> Immune System Diseases >> Autoimmune
Immunology >> Adaptive Immunity >> T Cells >> CD
Immunology >> Adaptive Immunity >> T Cells >> Cytotoxic Cells
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Relevance
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CTLA4 has a critical role in T cell differentiation and contributes to the maintenance of peripheral T cell tolerance to self antigens. It exerts its major effects on T cell immune responses via regulation of the cell cycle and may be involved in T cell activation. It binds to B7-1 (CD80) and B7-2 (CD86), and it contains one immunoglobulin-like V type domain. It is widely expressed, with highest levels in lymphoid tissues.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 12477 (Mouse)
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Purity
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Immunogen affinity purified
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Storage buffer
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PBS, pH 7.4, no preservative, sterile filtered
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CTLA4 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CTLA4
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