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Product Name
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CXCR3 antibody [2Ar1]
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See all CXCR3 antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [2Ar1] to CXCR3
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Immunogen
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NS0 cells transfected with human CXCR3.
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Reacts with
(species key)
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Hu
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Specificity
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ab64714 reacts specifically with CXCR3 transfectants and not the parental cell line, using FACS analysis. Does not crossreact with CXCR1, CXCR2, CXCR4 or transfectants.
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Tested applications
(see key)
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Flow Cyt, IHC-Fr, IHC-P, Neut
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use at a concentration of 5 - 10 µg/ml. Add 10µl to 1-2.5x105 cells in total reaction volume 200µl.
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
Neut: Use at a concentration of 1 - 6 µg/ml in the presence of 7ng/ml of rhl-TAC, using the hCXCR3 transfected BaF/3 cells in a chemotaxis assay.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Other
Immunology >> Innate Immunity >> Chemokines >> Alpha Chemokine Rec. (CXCR)
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Relevance
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CXCR3 is a receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 2 may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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2Ar1
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Myeloma
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NS0
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Isotype
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IgG1
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
Constituents: 5% Trehalose, PBS, pH 7.2
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Purification notes
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Endotoxin Level: < 0.1EU/1ug (LAL methodology).
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CXCR3 antibody [2Ar1] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CXCR3
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CXCR3 antibody [2Ar1] - more information
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Customer reviews (feedback) regarding CXCR3 antibody [2Ar1] |
Customer FAQs regarding CXCR3 antibody [2Ar1] |
Protocols for CXCR3 antibody [2Ar1] |
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CXCR3 antibody [2Ar1] - related products:
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CXCR3 antibody [2Ar1] - other tools:
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