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Products:Immunology >> Innate Immunity >> Chemokines >> Alpha Chemokine Rec. (CXCR)
Overview
Product name
Anti-CXCR3 antibody
See all CXCR3 products (7) ...
Description
Rabbit polyclonal to CXCR3
Specificity
This antibody detects endogenous levels of total CXCR3 protein.
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
A synthesized peptide derived from the internal region of human CXCR3.
Positive control
Extracts from K562 cells.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Chemokines
Signal Transduction >> Signaling Pathway >> G Protein Signaling >> GPCR
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Other
Immunology >> Innate Immunity >> Chemokines >> Alpha Chemokine Rec. (CXCR)
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Western blot - CXCR3 antibody (ab77907)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab77907 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Detects a band of approximately 35 , 41 kDa (predicted molecular weight: 41 kDa).
ELISA
ELISA: 1/5000ELISA: 1/5000
Target
Function
Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). May play a role in angiogenesis.
Isoform 3 mediates the activity of CXCL11.
Tissue specificity
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP49682
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- C-X-C chemokine receptor type 3 antibody
- CD 183 antibody
- CD183 antibody
see all
Database links
- Entrez Gene: 2833 Human
- Omim: 300574 Human
- SwissProt: P49682 Human
- Unigene: 198252 Human
Anti-CXCR3 antibody images:
Western blot - CXCR3 antibody (ab77907)
All lanes : Anti-CXCR3 antibody (ab77907) at 1/500 dilution
Lane 1 : Extracts from K562 cells
Lane 2 : Extracts from K562 cell with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size : 41 kDa
Observed band size : 41 kDa
Additional bands at : 35 kDa. We are unsure as to the identity of these extra bands.
References for Anti-CXCR3 antibody (ab77907)
This product has been referenced in:
- Gregorovic Get al. Cellular Gene Expression That Correlates with EBER Expression in Epstein-Barr Virus-Infected Lymphoblastoid Cell Lines. J Virol 85:3535-45 (2011). WB; Human.Read more (PubMed: 21248031) »
See 1 publication for this product
Publishing research using ab77907? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"