Anti-CYP24A1 antibody (ab54594)

Overview

• Product nameAnti-CYP24A1 antibodySee all CYP24A1 primary antibodies ...
• Description
  Mouse monoclonal to CYP24A1
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Recombinant Fragment
  Predicted to work with: Mouse, Human
• Immunogen

  Recombinant fragment: LMLNTQVLGS SEDNFEDSSQ FRPERWLQEK EKINPFAHLP FGVGKRMCIG RRLAELQLHL ALCWIVRKYD IQATDNEPVE MLHSGTLVPS RELPIAFCQR , corresponding to amino acids 415-515 of Human CYP24A1

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2a
• Light chain typekappa
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Cytochromes

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Lipid and lipoprotein metabolism
  • Lipases

  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Cofactors, Vitamins / minerals
  • Vitamins / minerals

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Signal Transduction
  • Metabolism
  • Vitamins / Minerals

  • Cardiovascular
  • Lipids / Lipoproteins
  • Lipid Metabolism
  • Cytochromes

Applications

Target

• FunctionHas a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
• Sequence similaritiesBelongs to the cytochrome P450 family.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession Q07973 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 1591 Human
  • Entrez Gene: 13081 Mouse
  • Omim: 126065 Human
  • SwissProt: Q07973 Human
  • SwissProt: Q64441 Mouse
  • Unigene: 89663 Human
  • Unigene: 6575 Mouse

• Alternative names
  1 25 @dihydroxyvitamin D3 24 hydroxylase antibody1 25 dihydroxyvitamin D(3) 24 hydroxylase antibody1 antibody

  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial antibody24 ohase antibody24-OHase antibody25-dihydroxyvitamin D(3) 24-hydroxylase antibodyCP 24 antibodyCP24 antibodyCP24A_HUMAN antibodyCYP 24 antibodyCYP24 antibodyCYP24A1 antibodyCytochrome P450 24A1 antibodyCytochrome P450 24A1 mitochondrial antibodyCytochrome P450 family 24 antibodyCytochrome P450 family 24 subfamily A polypeptide 1 antibodyCytochrome P450 subfamily XXIV antibodyCytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) antibodyCytochrome P450-CC24 antibodyEC 1.14.13.n4 antibodyExo mitochondrial protein antibodyHCAI antibodyMGC126273 antibodyMGC126274 antibodymitochondrial antibodyP450 CC24 antibodyVitamin D 24 hydroxylase antibodyVitamin D(3) 24 hydroxylase antibodyVitamin D(3) 24-hydroxylase antibody

  see all

Anti-CYP24A1 antibody images

• 

  Western blot - CYP24A1 antibody (ab54594)
  Western blot against tagged recombinant protein immunogen using ab54594 CYP24A1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

  This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.