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Anti-CaMKII antibody (ab19223)

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Overview

Product name

Anti-CaMKII antibody
See all CaMKII products (10) ...

Description

Rabbit polyclonal to CaMKII

Specificity

This antibody recognizes alpha, delta and gamma isoforms of human, mouse, rat, bovine, hamster, guinea pig, chicken and rabbit CaMKII. It is not expected to react with the beta isoform.

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Rabbit, Chicken, Guinea pig, Hamster, Cow, Human

Immunogen

Synthetic peptide: CTRFTDEYQLFEEL conjugated to KLH, corresponding to N terminal amino acids 7-20 of Rat CaMKII (delta isoform )

CTRFTDEYQL FEEL

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 1mg/ml Borate buffered saline, pH 8.2

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab19223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    WB

     WB: Use a concentration ...Read more →

    WB: Use a concentration of 1 µg/mlDetects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).

Target

Function

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.

Cellular localization

Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse. Postsynaptic lipid rafts.

Target information above from: UniProt accessionQ9UQM7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Calcium/calmodulin dependent protein kinase II alpha antibody
  • Calcium/calmodulin dependent protein kinase II alpha B subunit antibody
  • Calcium/calmodulin dependent protein kinase II beta antibody
  • Calcium/calmodulin dependent protein kinase II delta antibody
  • Calcium/calmodulin dependent protein kinase II gamma antibody
  • calcium/calmodulin dependent protein kinase IIA antibody
  • Calcium/calmodulin dependent protein kinase type II alpha chain antibody
  • Calcium/calmodulin dependent protein kinase type II antibody
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha antibody
  • CaM kinase II alpha antibody
  • CaM kinase II alpha chain antibody
  • CaM kinase II alpha subunit antibody
  • CaM kinase II antibody
  • CaM kinase II beta antibody
  • CaM kinase II delta antibody
  • CaM kinase II gamma antibody
  • CaM kinase II subunit alpha antibody
  • CAMK 2 antibody
  • CAMK 2A antibody
  • CaMK II alpha subunit antibody
  • CaMK II antibody
  • CaMK-II subunit alpha antibody
  • CAMK2 antibody
  • CAMK2A antibody
  • CAMK2B antibody
  • CAMK2D antibody
  • CAMK2G antibody
  • CAMKA antibody
  • KCC2A_HUMAN antibody
  • KIAA0968 antibody
see all

References for Anti-CaMKII antibody (ab19223)

This product has been referenced in:

  • Chardonnet Set al. Large-scale study of phosphoproteins involved in long-term potentiation in the rat dentate gyrus in vivo. Eur J Neurosci 27:2985-98 (2008). WB; Rat.Read more (PubMed: 18588538) »
  • Wei Yet al. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Mol Pharmacol 71:835-42 (2007).Read more (PubMed: 17164407) »

See all 2 publications for this product

Publishing research using ab19223? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"