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Product Name
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CaMKII antibody
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See all CaMKII antibodies (9)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to CaMKII
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Immunogen
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Synthetic peptide: CTRFTDEYQLFEEL conjugated to KLH, corresponding to N terminal amino acids 7-20 of Rat CaMKII (delta isoform )
BLAST 'CTRFTDEYQLFEEL' with  or 
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Reacts with
(species key)
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Hu, Ms, Rat, Chk, Cow, Gpig, Hm, Rb
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Specificity
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This antibody recognizes alpha, delta and gamma isoforms of human, mouse, rat, bovine, hamster, guinea pig, chicken and rabbit CaMKII. It is not expected to react with the beta isoform.
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell membrane; presynaptic membrane. Cell junction; synapse.
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Research areas
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Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Heart >> Hypertrophy >> Other
Neuroscience >> Neurotransmission >> Calcium Signaling >> Calmodulin / CaMK
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Relevance
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CaMKII (Calcium/calmodulin-dependent protein kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma, and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits.
CaMKII is a prominent kinase in the central nervous system that may function in long term potentiation and neurotransmitter release.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: None
Constituents: Borate buffered saline, pH 8.2.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CaMKII antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for CaMKII antibody (ab19223)
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This product has been used in:
Wei Y et al. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Mol Pharmacol 71:835-42 (2007). PubMed: 17164407
If you publish research using ab19223 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to CaMKII
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