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Products:Neuroscience >> Neurotransmission >> Calcium Signaling >> Calmodulin / CaMK
Overview
Product name
Anti-CaMKII antibody
See all CaMKII products (10) ...
Description
Rabbit polyclonal to CaMKII
Specificity
This antibody recognizes alpha, delta and gamma isoforms of human, mouse, rat, bovine, hamster, guinea pig, chicken and rabbit CaMKII. It is not expected to react with the beta isoform.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Rabbit, Chicken, Guinea pig, Hamster, Cow, Human
Immunogen
Synthetic peptide: CTRFTDEYQLFEEL conjugated to KLH, corresponding to N terminal amino acids 7-20 of Rat CaMKII (delta isoform )
CTRFTDEYQL FEEL
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 1mg/ml Borate buffered saline, pH 8.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Heart >> Hypertrophy >> Other
Neuroscience >> Neurotransmission >> Calcium Signaling >> Calmodulin / CaMK
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19223 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlDetects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
Target
Function
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.
Cellular localization
Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse. Postsynaptic lipid rafts.
Target information above from: UniProt accessionQ9UQM7
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Calcium/calmodulin dependent protein kinase II alpha antibody
- Calcium/calmodulin dependent protein kinase II alpha B subunit antibody
- Calcium/calmodulin dependent protein kinase II beta antibody
see all
Database links
- Entrez Gene: 374174 Chicken
- Entrez Gene: 374175 Chicken
- Entrez Gene: 422688 Chicken
- Entrez Gene: 423737 Chicken
- Entrez Gene: 282162 Cow
- Entrez Gene: 525416 Cow
- Entrez Gene: 530719 Cow
- Entrez Gene: 532713 Cow
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References for Anti-CaMKII antibody (ab19223)
This product has been referenced in:
- Chardonnet Set al. Large-scale study of phosphoproteins involved in long-term potentiation in the rat dentate gyrus in vivo. Eur J Neurosci 27:2985-98 (2008). WB; Rat.Read more (PubMed: 18588538) »
- Wei Yet al. Dopamine transporter activity mediates amphetamine-induced inhibition of Akt through a Ca2+/calmodulin-dependent kinase II-dependent mechanism. Mol Pharmacol 71:835-42 (2007).Read more (PubMed: 17164407) »
See all 2 publications for this product
Publishing research using ab19223? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"