CaV1.3 antibody [S38-8] (ab84811)

Product Name 

CaV1.3 antibody [S38-8]

Product type 

Primary antibodies

Description 

Mouse monoclonal [S38-8] to CaV1.3

Immunogen 

Fusion protein corresponding to C terminal amino acids 2025-2161 of Rat Cav1.3

Reacts with 
(species key)

Hu, Ms, Rat

Specificity 

No cross-reactivity against Cav1.2

Tested applications 
(see key)

ICC/IF, IP, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ICC/IF: Use at a concentration of 0.1 - 1 µg/ml (Perox), 1 -1 0 µg/ml (IF).
IP: Use at an assay dependent dilution.
WB: Use at a concentration of 1 - 10 µg/ml. Predicted molecular weight: 245 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Rat brain lysate

Cellular localization 

Membrane. Multi-pass membrane protein.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Channels
Neuroscience >> Neurotransmission >> Calcium Signaling >> Calcium Channels >> L-type

Relevance 

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the "high-voltage activated" (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

S38-8

Isotype 

IgG1

Purity 

Protein G purified

Storage buffer 

Preservative: 0.09% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.4

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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