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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CaV1.3 antibody [S48A-9] (ab85491)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CaV1.3 antibody [S48A-9] (ab85491)](/ps/datasheet/images/85/ab85491/CaV13-Primary-antibodies-ab85491-1.jpg)
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Product Name
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CaV1.3 antibody [S48A-9]
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See all CaV1.3 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [S48A-9] to CaV1.3
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Immunogen
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Synthetic peptide: DNKVTIDDYQEEAEDKD, corresponding to N terminal amino acids 859-875 of rat CaV1.3 (SwissProt P27732).
BLAST 'DNKVTIDDYQEEAEDKD' with  or 
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Reacts with
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Hu, Ms, Rat
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Predicted to react
(species key)
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Hm
(Due to sequence homology)
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Specificity
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No cross reactivity against CaV1.2.
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Tested applications
(see key)
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ICC/IF, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ICC: Use at a concentration of 0.1 - 1 µg/ml.
ICC/IF: Use at a concentration of 1 - 10 µg/ml.
IP: Use at an assay dependent dilution.
WB: Use at a concentration of 1 - 10 µg/ml. Predicted molecular weight: 245 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Rat brain lysate.
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Cellular localization
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Membrane. Multi-pass membrane protein.
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Channels
Neuroscience >> Neurotransmission >> Calcium Signaling >> Calcium Channels >> L-type
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Relevance
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Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the "high-voltage activated" (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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S48A-9
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Isotype
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IgG2a
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.09% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.4 Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CaV1.3 antibody [S48A-9] is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for CaV1.3 antibody [S48A-9] images, references, products related to ab85491 and other tools.
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CaV1.3 antibody [S48A-9] images:
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 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CaV1.3 antibody [S48A-9] (ab85491)
ab85491 staining CaV1.3 in mouse backskin tissue by IHC-P (Bouin's fixed paraffin embedded sections).
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Search PubMed (MEDLINE) for references to CaV1.3
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CaV1.3 antibody [S48A-9] - more information
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Customer reviews (feedback) regarding CaV1.3 antibody [S48A-9] |
Customer FAQs regarding CaV1.3 antibody [S48A-9] |
Protocols for CaV1.3 antibody [S48A-9] |
Price and availability of products related to CaV1.3 antibody [S48A-9] |
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CaV1.3 antibody [S48A-9] - related products:
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CaV1.3 antibody [S48A-9] - other tools:
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Contact Abcam with a Technical Enquiry about CaV1.3 antibody [S48A-9] |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CaV1.3 antibody [S48A-9] (ab85491)](/index.html?datasheet=85491#CaV13-Primary-antibodies-ab85491-1.jpg)
