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Product Name 

CaV1.3 antibody

 

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Product type 

Primary antibodies

Description 

Rabbit polyclonal to CaV1.3

Immunogen 

A synthetic peptide from the cytoplasmic domain of human CaV1.3, conjugated to an immunogenic carrier protein.

Reacts with 
(species key)

Hu, Ms, Rat

Tested applications 
(see key)

IHC-Fr, IHC-P, WB


Abreviews 

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Application notes 
(see key)

Recommended dilutions
IHC-P: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 245 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Membrane. Multi-pass membrane protein.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calcium Channels
Neuroscience >> Neurotransmission >> Calcium Signaling >> Calcium Channels >> L-type

Relevance 

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the "high-voltage activated" (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

 

Alternative names CaV1.3 antibody (ab81096)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

776    (Human)
12289    (Mouse)
29716    (Rat)

Omim

    

114206    (Human)

SwissProt

    

Q01668    (Human)
Q99246    (Mouse)
P27732    (Rat)

Unigene

    

476358    (Human)

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

IgG fraction

Storage buffer 

Preservative: None
Constituents: 1X PBS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CaV1.3 antibody is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to CaV1.3

 

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