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Read our guarantee »Products:Neuroscience >> Neurotransmission >> Calcium Signaling >> Calcium Channels >> L-type
Anti-CaV1.3 antibody
See all CaV1.3 products (5) ...
Rabbit polyclonal to CaV1.3
WB, IHC-P, IHC-Frmore details
Reacts with
Mouse, Rat, Human
A synthetic peptide from the cytoplasmic domain of human CaV1.3, conjugated to an immunogenic carrier protein.
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
Preservative: None
Constituents: 1X PBS
Concentration information loading...
IgG fraction
Polyclonal
IgG
Our Abpromise guarantee covers the use of ab81096 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at a concentration of 10 - 50 µg/ml. Antigen retrieval is recommended.
IHC-Fr: Use at a concentration of 10 - 50 µg/ml.
WB: Use at a concentration of 10 - 50 µg/ml. Predicted molecular weight: 245 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle.
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily.
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Membrane.
Target information above from: UniProt accessionQ01668
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab81096 has not yet been referenced specifically in any publications.
Publishing research using ab81096? Please let us know so that we can cite the reference in this datasheet
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