Anti-Calcium binding protein P22 antibody (ab56953)

Overview

• Product nameAnti-Calcium binding protein P22 antibodySee all Calcium binding protein P22 primary antibodies ...
• Description
  Mouse monoclonal to Calcium binding protein P22
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant full length protein: MESHSVTQAG VQWRDLGSLQ PLPPGFKQFS HLSLPSSWDY RRVPPYLGNF CIFSGEGVSP CWPGWS, corresponding to amino acids 0-0 of Human Calcium binding protein P22

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Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG2a
• Light chain typekappa
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

Applications

Target

• FunctionRequired for constitutive membrane traffic. Inhibits GTPase-stimulated Na(+)/H(+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.
• Tissue specificityUbiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.
• Sequence similaritiesContains 4 EF-hand domains.
• Post-translational
  modificationsBoth N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic.
  Phosphorylated; decreased phosphorylation is associated with an increase in exchange activity. The phosphorylation state may regulate the binding to NHE1.
• Cellular localizationCytoplasm.

Target information above from: UniProt accession Q99653 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 11261 Human
  • Omim: 606988 Human
  • SwissProt: Q99653 Human
  • Unigene: 406234 Human
  • Unigene: 706184 Human

• Alternative names
  Calcineurin B homolog antibodyCalcineurin B homologous protein antibodyCalcineurin homologous protein antibody

  Calcium binding protein CHP antibodyCalcium binding protein p22 antibodyCalcium-binding protein CHP antibodyCalcium-binding protein p22 antibodychp antibodyCHP1_HUMAN antibodySid 470 antibodySid470 antibodySLC9A1 binding protein antibodySLC9A1BP antibodyWrch2 antibody

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Anti-Calcium binding protein P22 antibody images

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  Western blot - Calcium binding protein P22 antibody (ab56953)
  Western blot against tagged recombinant protein immunogen using ab56953 Calcium binding protein P22 antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa