|
|
|
|
|
Product Name
|
Calpain 10 peptide
|
|
Product type
|
Proteins and Peptides
|
|
Peptide
|
Synthetic peptide Calpain 10.
This peptide was used as an immunogen for ab28222 - Calpain 10 antibody - Aminoterminal end domain I.
|
|
Specificity
|
We have a range of domain specific antibodies for this target. For a full list please see all Calpain 10 antibodies
|
|
Tested applications
(see key)
|
ELISA, WB
|
|
Application notes
(see key)
|
Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28222. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
|
|
Research areas
|
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Cysteine protease >> Calpains
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Calpain
|
|
Relevance
|
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain.
Calpain 10 is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. It is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and the gene is located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described.
|
|
|
Calpain 10 peptide (ab44842) |
|
Purity
|
>95% by SDS-PAGE
|
|
Storage buffer
|
Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
|
|
Form
|
Liquid
|
|
Concentration
|
1.000 mg/ml
|
|
Storage instructions
|
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Calpain 10 peptide is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
| |
|
Search PubMed (MEDLINE) for references to Calpain 10
|
| |
Calpain 10 peptide - more information
|
Customer reviews (feedback) regarding Calpain 10 peptide |
Customer FAQs regarding Calpain 10 peptide |
Protocols for Calpain 10 peptide |
Price and availability of products related to Calpain 10 peptide |
| |
Calpain 10 peptide - related products:
|
|
|
| |
Calpain 10 peptide - other tools:
|
Contact Abcam with a Technical Enquiry about Calpain 10 peptide |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
