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Overview

  • Product nameAnti-Calpain 7 antibodySee all Calpain 7 primary antibodies ...
  • Description
    Rabbit polyclonal to Calpain 7
  • SpecificityThis antibody does not cross react with the other calpain family members (calpain 1, calpain 2, Calpain 3, ncl 3, etc.)
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide based on Domain III of the large subunit of human calpain 7. (Peptide available as ab41350.)

  • EpitopeThis antibody reacts to the carboxy end of Domain III of Calpain 7.

Properties

Applications

Our Abpromise guarantee covers the use of ab28213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: 1/1000 - 1/5000. Detects a band of approximately 93kDa, also a band at 68 kDa and further bands due to the presence of cleaved forms, under reducing conditions. (predicted molecular weight: 93 kDa). Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceCalpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain 4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (Calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain 7). Calpain 7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, Calpain 7 has a sequence most closely resembling domain-III, with unknown function. Calpain 7 is widely distributed, found in most tissues analyzed.
    • Cellular localizationNuclear
    • Database links
      see all
    • Alternative names
        Calpain like protease antibodyCalpain7 antibodyCAPN 7 antibody
        Homolog of Aspergillus Nidulans PALB antibodyPALBH antibody
      see all

    References for Anti-Calpain 7 antibody (ab28213)

    ab28213 has not yet been referenced specifically in any publications.

    Publishing research using ab28213 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"