Anti-Calreticulin antibody (ab19261)

Overview

• Product nameAnti-Calreticulin antibodySee all Calreticulin primary antibodies ...
• Description
  Rabbit polyclonal to Calreticulin
• Tested applicationsWB, ICC, IP more details
• Species reactivity
  Reacts with: Mouse, Rat, Rabbit, Chicken, Guinea pig, Hamster, Human, Pig, Monkey
  
• Immunogen

  Synthetic peptide: EEEDVPGQAKDEL conjugated to KLH, corresponding to amino acids 405-417 of Human Calreticulin.

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Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Trafficking
  • Organelle Proteins

  • Tags & Cell Markers
  • Subcellular Markers
  • Organelles
  • ER

Applications

Target

• FunctionMolecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.
• Sequence similaritiesBelongs to the calreticulin family.
• DomainCan be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
  The interaction with glycans occurs through a binding site in the globular lectin domain.
  The zinc binding sites are localized to the N-domain.
  Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
• Cellular localizationEndoplasmic reticulum lumen. Cytoplasm > cytosol. Secreted > extracellular space > extracellular matrix. Cell surface. Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.

Target information above from: UniProt accession P27797 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 811 Human
  • Entrez Gene: 12317 Mouse
  • Entrez Gene: 64202 Rat
  • Omim: 109091 Human
  • SwissProt: P27797 Human
  • SwissProt: Q3TVD2 Mouse
  • SwissProt: P14211 Mouse
  • SwissProt: P28491 Pig

  • SwissProt: P15253 Rabbit
  • SwissProt: P18418 Rat
  • Unigene: 515162 Human
  • Unigene: 1971 Mouse
  • Unigene: 467043 Mouse
  • Unigene: 974 Rat

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• Alternative names
  Autoantigen Ro antibodyCALR antibodyCALR protein antibody

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