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Overview

  • Product nameCalsequestrin proteinSee all Calsequestrin proteins and peptides ...
  • Protein descriptionRecombinant fragment corresponding to amino acids 35-136 of Human Calsequestrin with an N terminal proprietary tag; predicted mwt: 36.96 kDa inclusive of tag (UniProt ID: P31415).
  • Uniprot accessionP31415
  • Molecular weight36.960kDa inclusive of tags
  • Protein length102 amino acids
  • Expression hostWheat germ

    • Properties

  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
  • Sequence notesQEGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEP PEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKD AAVAKKLGLTEVDSMYVFKGDE
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab114404 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent concentration.
    WB WB: Use at an assay dependent concentration. (for recombinabt protein).
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        CalmitinCalsequestrinCalsequestrin 1
        Calsequestrin 1 fast twitch skeletal muscleCalsequestrin 2Calsequestrin 2 fast twitch cardiac muscleCalsequestrin cardiac muscle isoformCalsequestrin skeletal muscle isoformCalsequestrin-1Cardiac calsequestrin 2CASQ 1CASQ 2Casq1CASQ1_HUMANPDIB1PDIB2Skeletal muscle calsequestrin 1skeletal muscle isoform
      see all
  • FunctionCalsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin.
  • Sequence similaritiesBelongs to the calsequestrin family.
  • Cellular localizationSarcoplasmic reticulum lumen. Mitochondrion. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.

    • Target information above from: UniProt accession P31415 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Calsequestrin protein images

    • SDS-PAGE - Calsequestrin protein (ab114404)
      SDS-PAGE - Calsequestrin protein (ab114404)
      12.5% SDS-PAGE analysis of ab114404, stained with Coomassie Blue

    References for Calsequestrin protein (ab114404)

    ab114404 has not yet been referenced specifically in any publications.

    Publishing research using ab114404 ? Please let us know so that we can cite the reference in this datasheet

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