Overview

  • Product name
    Cambinol
  • Description
    SIRT1/2 inhibitor
  • Biological description
    SIRT1/2 inhibitor (IC50 values are 56 and 59 μM at SIRT1 and SIRT2 respectively). Class III HDAC inhibitor, with no inhibition of class I and II. Promotes G2 cell cycle arrest. Antitumour activity in vitro and in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Lautz TB  et al. Efficacy of class I and II vs class III histone deacetylase inhibitors in neuroblastoma. J Pediatr Surg 47:1267-71 (2012). Read more (PubMed: 22703804) »
  • Heltweg B  et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 66:4368-77 (2006). Read more (PubMed: 16618762) »
  • Tervo AJ  et al. Discovering inhibitors of human sirtuin type 2: novel structural scaffolds. J Med Chem 49:7239-41 (2006). Read more (PubMed: 17125277) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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