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Product name
Camptothecin
Cross reactivity
Induces apoptosis in Jurkat cells, Osteosarcoma and hepatoma cells
General notes
This product is provided at 2 mM in DMSO.
Properties
Form
Liquid
Storage instructions
Store at -20°C, Stable for 6 months at -20°C
Storage buffer
Molecular Weight: 348.4
Molecular Formula:C20H16N2O4
Purity: >98% by TLC
Concentration
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Research areas
Kits/ Lysates/ Other >> Kits >> Apoptosis Kits >> Apoptosis inducers/ reagents
Kits/ Lysates/ Other >> Kits >> Cell Damage Kits >> DNA damage and cell cycle arrest
Cancer >> Drug resistance >> Topoisomerases
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Synthesis >> Topoisomerases
Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> HIV
Relevance
Camptothecin binds reversibly to inhibit nuclear topoisomerase I and stabilizes the topoisomerase-DNA covalent complex. Camptothecin also inhibits Tat-mediated transcription of HIV-1. Jurkat, Osteosarcoma and Hepatoma cells apoptosis can be induced by Camptothecin.
Alternative names
- Camptothecin
Applications
Application notes
Use 1000X dilutions for inducing apoptosis in Jurkat cells. However, the optimal doses may vary for different cells and culture conditions.
References for Camptothecin (ab39758)
ab39758 has not yet been referenced specifically in any publications.
Publishing research using ab39758? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"