Cancer Antigen CA125 Human ELISA Kit (ab108653)
- Product nameCancer Antigen CA125 Human ELISA Kit
- Tests1 x 96 well plate
- Sample typeSerum
- Assay typeSandwich
- Sensitivity= 5 U/ml
- Range5 U/ml - 400 U/ml
- Species reactivityReacts with: Human
- Product overview
ab108653 is for the quantitative determination of the Cancer Antigen CA125 concentration in human serum.
Cancer Antigen 125 (CA125) is a surface antigen associated with epithelial ovarian cancer. In serum, CA125 is associated with a high molecular weight glycoprotein. Published studies have indicated that elevated serum CA125 levels can be found in individuals with serious endometroid, clear-cell and undifferentiated ovarian carcinoma.
The serum CA125 concentration is greater than 35 units per ml in 60% of women with ovarian cancer and >80% of patients with disseminated ovarian cancer. The serum CA125 is elevated in 1% of normal healthy women, 3% of normal healthy women with benign ovarian diseases, and 6% of patients with non-neoplastic conditions (including but not limited to first trimester pregnancy, menstruation, endometriosis, uterine fibrosis, acute salphingitis, hepatic diseases and inflammation of peritoneum, pericardium or pleura). Serum CA125 concentration may be useful in monitoring treatment and distinguishing between good response to treatment and progressive malignant disease with poor therapeutic response. To date, CA125 is the most sensitive marker for residual epithelial ovarian cancer.
- Tested applicationsELISA more details
- Storage instructionsStore at +4°C. Please refer to protocols.
Components 1 x 96 tests CA125 reference standards containing; 0, 15, 50, 100, 200, and 400 Unit/ml of CA125 6 x 1ml Enzyme Conjugate Reagent 1 x 13ml Murine Monoclonal anti-CA125 coated microtiter plate 1 unit Stop Solution 1 x 11ml TMB Reagent 1 x 11ml Wash Buffer Concentrate 1 x 50ml
- Research Areas
Contains 56 SEA domains.
modificationsHeavily O-glycosylated; expresses both type 1 and type 2 core glycans.
Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
- CA 125CA-125CA125
- MUC 16MUC-16MUC16MUC16_HUMANMucin 16Mucin-16Ovarian cancer related tumor marker CA125Ovarian cancer-related tumor marker CA125Ovarian carcinoma antigen CA125
Our Abpromise guarantee covers the use of ab108653 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
References for Cancer Antigen CA125 Human ELISA Kit (ab108653)
ab108653 has not yet been referenced specifically in any publications.