Overview

  • Product name
    Carbamazepine
  • Description
    Neuronal voltage-gated Na+ channel blocker
  • Biological description
    Neuronal voltage-gated Na+ channel blocker. Shows anticonvulsant effects in vivo. Attenuates neuropathic pain behaviours. Potent GABAA current potentiator (EC50 = 25 nM). Orally and centrally active.
  • Purity
    > 98%

Properties

  • Chemical name
    Benzo[b][1]benzazepine-11-carboxamide
  • Molecular weight
    236.30
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H12N2O
  • CAS Number
    289-46-4
  • PubChem identifier
    2554
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
  • Source

    Synthetic

  • Research areas

Images

  • Carbamazepine inhibits Nav1.2 channels currents in Xenopusoocytes.

    A. Time course of NaV1.2 channel reversible inhibition by 100 µM and 1 mM Carbamazepine (ab141785). Currents were elicited by a voltage step to -20 mV (100 ms) every 10 seconds from a holding potential of -100 mV. 

    B. Example traces of current response to voltage step application before and during 1 mM Carbamazepine application.

References

This product has been referenced in:
  • Hahm TS  et al. Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. Br J Anaesth 109:968-74 (2012). Read more (PubMed: 22936823) »
  • Lipkind GM & Fozzard HA Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol Pharmacol 78:631-8 (2010). Read more (PubMed: 20643904) »
  • Granger P  et al. Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol Pharmacol 47:1189-96 (1995). Read more (PubMed: 7603459) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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