Neuronal voltage-gated Na+ channel blocker. Shows anticonvulsant effects in vivo. Attenuates neuropathic pain behaviours. Potent GABAA current potentiator (EC50 = 25 nM). Orally and centrally active.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Carbamazepine inhibits Nav1.2 channels currents in Xenopusoocytes.
A. Time course of NaV1.2 channel reversible inhibition by 100 µM and 1 mM Carbamazepine (ab141785). Currents were elicited by a voltage step to -20 mV (100 ms) every 10 seconds from a holding potential of -100 mV.
B. Example traces of current response to voltage step application before and during 1 mM Carbamazepine application.