Anti-Cardiac Troponin T antibody (ab129696)

Overview

• Product nameAnti-Cardiac Troponin T antibodySee all Cardiac Troponin T primary antibodies ...
• Description
  Rabbit polyclonal to Cardiac Troponin T
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 171-201 of Human Cardiac Troponin T (Accessions: P45379, NP_001001431.1, NP_001001430.1).

• Positive controlMouse heart tissue lysates

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesThis antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Mesenchymal Stem Cells
  • Myogenesis

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microfilaments
  • Actin etc
  • Troponin

  • Cardiovascular
  • Cardiovascular Markers
  • Cell Markers
  • Cardiomyocytes

  • Cardiovascular
  • Heart
  • Contractility
  • Contractile Proteins
  • Troponin

Applications

Target

• FunctionTroponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
• Tissue specificityHeart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
• Involvement in diseaseDefects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2) [MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [MIM:601494]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3) [MIM:612422]. Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
• Sequence similaritiesBelongs to the troponin T family.

Target information above from: UniProt accession P45379 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7139 Human
  • Entrez Gene: 21956 Mouse
  • Omim: 191045 Human
  • SwissProt: P45379 Human
  • SwissProt: P50752 Mouse
  • Unigene: 533613 Human
  • Unigene: 247470 Mouse

• Alternative names
  Cardiac muscle troponin T antibodyCardiomyopathy dilated 1D (autosomal dominant) antibodyCardiomyopathy hypertrophic 2 antibody

  CMD1D antibodyCMH2 antibodyCMPD2 antibodycTnT antibodyLVNC6 antibodyMGC3889 antibodyOTTHUMP00000033864 antibodyOTTHUMP00000033865 antibodyOTTHUMP00000033866 antibodyOTTHUMP00000033867 antibodyOTTHUMP00000033870 antibodyOTTHUMP00000218095 antibodyRCM3 antibodyTNNT 2 antibodyTNNT2 antibodyTNNT2_HUMAN antibodyTnTc antibodyTroponin T cardiac muscle antibodyTroponin T type 2 (cardiac) antibodyTroponin T type 2 cardiac antibodyTroponin T, cardiac muscle antibodyTroponin T2 cardiac antibody

  see all

Anti-Cardiac Troponin T antibody images

• 

  Western blot - Anti-Cardiac Troponin T antibody (ab129696)
  Anti-Cardiac Troponin T antibody (ab129696) at 1/100 dilution + Mouse heart tissue lysates at 35 µg
  
  Predicted band size : 35 kDa