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Cardiac Troponin T protein (His tag) (ab86685)

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Overview

  • Product nameCardiac Troponin T protein (His tag)See all Cardiac Troponin T proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 1-285 of human Cardiac Troponin T fused to His tag at N-terminus; 305 amino acids, 36.4 kDa. Swiss ID = P45379
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesab86685 is purified using conventional chromatography techniques.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
  • Concentration information loading...
  • Sequence notesMGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab86685 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab10214,ab33589 and ab45932.

    • Protein info

    • Alternative names
        Cardiac muscle troponin TCardiomyopathy dilated 1D (autosomal dominant)Cardiomyopathy hypertrophic 2
        CMD1DCMH2CMPD2cTnTLVNC6MGC3889OTTHUMP00000033864OTTHUMP00000033865OTTHUMP00000033866OTTHUMP00000033867OTTHUMP00000033870OTTHUMP00000218095RCM3TNNT 2TNNT2TNNT2_HUMANTnTCTroponin T cardiac muscleTroponin T type 2 (cardiac)Troponin T type 2 cardiacTroponin T, cardiac muscleTroponin T2 cardiac
      see all
  • FunctionTroponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • Tissue specificityHeart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
  • Involvement in diseaseDefects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2) [MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [MIM:601494]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3) [MIM:612422]. Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
  • Sequence similaritiesBelongs to the troponin T family.

    • Target information above from: UniProt accession P45379 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Cardiac Troponin T protein (His tag) images

    References for Cardiac Troponin T protein (His tag) (ab86685)

    ab86685 has not yet been referenced specifically in any publications.

    Publishing research using ab86685 ? Please let us know so that we can cite the reference in this datasheet

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    Hello!
    I am interested in buying one of your products - recombinant human cardiac troponin T protein (His tag) (ab86685), but I have some questions, conserning the protein:
    According to the sequence that is presented on your site, the protein yo...

    Read More

    Thank you for contacting us.

    Q1. How can you explain the absence of exon 13 in the protein you are selling?
    Here's a link to our protein's description on NCBI: http://www.ncbi.nlm.nih.gov/protein/NP_001001431
    For some reason this part...

    Read More

    Hello!
    I am interested in buying one of your products - recombinant human cardiac troponin T protein (His tag) (ab86685), but I have some questions, conserning the protein:
    According to the sequence that is presented on your site, the protein yo...

    Read More

    Thank you for contacting us.

    We are currently investigating your inquiry. We will get back to you with the information soon.

    Many thanks for having patience!

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"